Effect of treatment frequency on the efficacy of superhydrophobic antimicrobial photodynamic therapy of periodontitis in a wistar rat model

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Autor(es): dc.contributorMassachusetts General Hospital and Harvard Medical School-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorThe Graduate Center of the City University of New York-
Autor(es): dc.contributorCity University of New York-
Autor(es): dc.contributorHarvard University and Massachusetts Institute of Technology-
Autor(es): dc.contributorVentureLink-
Autor(es): dc.creatorCoradi Tonon, Caroline-
Autor(es): dc.creatorde Souza Rastelli, Alessandra Nara-
Autor(es): dc.creatorBodahandi, Chathuna-
Autor(es): dc.creatorAshraf, Shoaib-
Autor(es): dc.creatorHasan, Tayyaba-
Autor(es): dc.creatorXu, QianFeng-
Autor(es): dc.creatorGreer, Alexander-
Autor(es): dc.creatorLyons, Alan M.-
Data de aceite: dc.date.accessioned2025-08-21T18:43:41Z-
Data de disponibilização: dc.date.available2025-08-21T18:43:41Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/php.14021-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301653-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301653-
Descrição: dc.descriptionSuperhydrophobic antimicrobial photodynamic therapy (SH-aPDT) is advantageous wherein airborne singlet oxygen (1O2) is delivered from a device tip to kill a biofilm with no photosensitizer exposure and no bacterial selectivity (Gram + or Gram −). For effective treatment of periodontitis, the frequency of treatment as well as the optical light fluence required is not known. Thus, we sought to determine whether single or repeated SH-aPDT treatments would work best in vivo using two fluence values: 60 and 125 J/cm2. We assessed the efficacy of three protocols: single treatment; interval treatments (days 0, 2, and 7); and consecutive treatments (days 0, 1, and 2). After 30 days of evaluation, we found that, SH-aPDT in 3 consecutive treatments significantly decreased Porphyromonas gingivalis levels compared to single and interval SH-aPDT treatments, as well as SRP-chlorhexidine (CHX) controls (p < 0.05). Notably, clinical parameters also improved (p < 0.05), and histological and stereometric analyses revealed that consecutive SH-aPDT treatments were the most effective for promoting healing and reducing inflammation. Our study shows what works best for SH-aPDT, while also demonstrating SH-aPDT advantages to treatment of periodontitis including no bacterial selectivity (Gram + or Gram −) and preventing the development of bacterial resistance.-
Descrição: dc.descriptionWellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical School-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Araraquara Sao Paulo State University-UNESP-
Descrição: dc.descriptionPh.D. Program in Chemistry The Graduate Center of the City University of New York-
Descrição: dc.descriptionDepartment of Chemistry College of Staten Island City University of New York-
Descrição: dc.descriptionDivision of Health Sciences and Technology Harvard University and Massachusetts Institute of Technology-
Descrição: dc.descriptionSingletO2 Therapeutics LLC VentureLink-
Descrição: dc.descriptionDepartment of Chemistry Brooklyn College City University of New York-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Araraquara Sao Paulo State University-UNESP-
Idioma: dc.languageen-
Relação: dc.relationPhotochemistry and Photobiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaPDT-
Palavras-chave: dc.subjectchlorhexidine-
Palavras-chave: dc.subjectconsecutive days of treatment-
Palavras-chave: dc.subjecthandheld device-
Palavras-chave: dc.subjectPorphyromonas gingivalis-
Palavras-chave: dc.subjectrepetitive treatments-
Palavras-chave: dc.subjectscaling and root planing-
Palavras-chave: dc.subjectSH-aPDT-
Palavras-chave: dc.subjectsinglet oxygen-
Título: dc.titleEffect of treatment frequency on the efficacy of superhydrophobic antimicrobial photodynamic therapy of periodontitis in a wistar rat model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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