Synthesis, Antibacterial Effects, and Toxicity of Licochalcone C

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorGuarulhos University-
Autor(es): dc.creatorOzanique, Patrick Rômbola-
Autor(es): dc.creatorHelena, Alvaro Luiz-
Autor(es): dc.creatorMenezes, Ralciane de Paula-
Autor(es): dc.creatorGonçalves, Daniela Silva-
Autor(es): dc.creatorSantiago, Mariana Brentini-
Autor(es): dc.creatorDilarri, Guilherme-
Autor(es): dc.creatorSardi, Janaína de Cássia Orlandi-
Autor(es): dc.creatorFerreira, Henrique-
Autor(es): dc.creatorMartins, Carlos Henrique Gomes-
Autor(es): dc.creatorRegasini, Luis Octávio-
Data de aceite: dc.date.accessioned2025-08-21T15:35:50Z-
Data de disponibilização: dc.date.available2025-08-21T15:35:50Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph17050634-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301647-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301647-
Descrição: dc.descriptionDrug-resistant bacteria constitute a big barrier against current pharmacotherapy. Efforts are urgent to discover antibacterial drugs with novel chemical and biological features. Our work aimed at the synthesis, evaluation of antibacterial effects, and toxicity of licochalcone C (LCC), a naturally occurring chalcone. The synthetic route included six steps, affording a 10% overall yield. LCC showed effects against Gram-positive bacteria (MIC = 6.2–50.0 µg/mL), Mycobacterium species (MIC = 36.2–125 µg/mL), and Helicobacter pylori (MIC = 25 µg/mL). LCC inhibited the biofilm formation of MSSA and MRSA, demonstrating MBIC50 values of 6.25 μg/mL for both strains. The investigations by fluorescence microscopy, using PI and SYTO9 as fluorophores, indicated that LCC was able to disrupt the S. aureus membrane, similarly to nisin. Systemic toxicity assays using Galleria mellonella larvae showed that LCC was not lethal at 100 µg/mL after 80 h treatment. These data suggest new uses for LCC as a compound with potential applications in antibacterial drug discovery and medical device coating.-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment Microbiology Institute of Biomedical Sciences Federal University of Uberlândia (UFU), MG-
Descrição: dc.descriptionDepartment of Biochemistry and Microbiology Institute of Biosciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDental Research Division Guarulhos University, SP-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Biochemistry and Microbiology Institute of Biosciences São Paulo State University (Unesp), SP-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantibacterial-
Palavras-chave: dc.subjectbiofilm-
Palavras-chave: dc.subjectchalcone-
Palavras-chave: dc.subjectdrug-resistant-
Palavras-chave: dc.subjectGalleria mellonella-
Palavras-chave: dc.subjectGlycyrrhiza-
Palavras-chave: dc.subjectlicochalcone-
Palavras-chave: dc.subjectmembrane-
Título: dc.titleSynthesis, Antibacterial Effects, and Toxicity of Licochalcone C-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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