Association of neutrophil extracellular trap levels with Raynaud's phenomenon, glomerulonephritis and disease index score in SLE patients from Brazil

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMackenzie Evangelical School of Medicine Paraná–Curitiba-
Autor(es): dc.contributorHospital Geral de Curitiba - Exército Brasileiro - Curitiba-
Autor(es): dc.contributorFederal University of Paraná-
Autor(es): dc.creatorDelabio Auer, Eduardo-
Autor(es): dc.creatorBumiller-Bini Hoch, Valéria-
Autor(es): dc.creatorBorges da Silva, Emiliano-
Autor(es): dc.creatorRicci Zonta, Yohan-
Autor(es): dc.creatorAlarcão Dias-Melicio, Luciane-
Autor(es): dc.creatorLarocca Skare, Thelma-
Autor(es): dc.creatorF. Picceli, Vanessa-
Autor(es): dc.creatorMessias-Reason, Iara José-
Autor(es): dc.creatorBoldt, Angelica Beate Winter-
Data de aceite: dc.date.accessioned2025-08-21T21:39:37Z-
Data de disponibilização: dc.date.available2025-08-21T21:39:37Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.imbio.2024.152803-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301645-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301645-
Descrição: dc.descriptionNeutrophil extracellular traps (NETs) are cell-extruded DNA strands coated with neutrophils' nuclear proteins and enzymes from cytotoxic granules, produced by NETosis, a cell death pathway. They perform an important defensive role in innate immunity, but their increased production and/or inefficient degradation expose new antigens, such as DNA or citrullinated histone peptides, triggering autoimmunity. This study aimed to access possible associations between serum NETs levels with epidemiological, clinical, and serological data from a well-characterized SLE Brazilian patients’ cohort. NET levels were evaluated in one hundred seventy serum samples of patients with Systemic Lupus Erythematosus (SLE) using an Immunoassay. Univariate and multivariate binary logistic regression used clinical patients' data as independent variables. Parametric and non-parametric tests compared log10 base serum NET levels transformed between patients' groups. SLE patients were also dichotomized into “High serum NET levels” and “Low serum NET levels” groups. All analyses were performed in R language 4.1.2, and p < 0.05 were considered significant. Increased susceptibility for high serum NET levels was observed in SLE patients with Raynaud's phenomenon (OR = 2.30, 95 % CI = 1.06–5.21 and p = 0.039), independently of any other risk factor. Also, SLE patients with Raynaud's phenomenon presented higher mean NET serum levels (mean = −0.13 vs. −0.51, p = 0.01). In addition, higher mean NET serum levels were associated with glomerulonephritis (mean = -0.45 vs. −0.12, p = 0.03). Ultimately, the SLEDAI index scored higher in the high NETs serum levels group (median = 2.0 vs. 0.0, p = 6 × 10−3). The formation of NETs might be implicated in Raynaud's phenomenon, glomerulonephritis, and disease index score in SLE patients. Our results highlight the importance of serum NET levels as a possible therapeutical target to modulate the clinical course of SLE.-
Descrição: dc.descriptionFundação Araucária-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPostgraduate Program in Genetics. Department of Genetics Federal University of Paraná (UFPR), Centro Politécnico, Jardim das Américas, Paraná-
Descrição: dc.descriptionFederal University of Paraná (UFPR), Centro Politécnico, Jardim das Américas, PR-
Descrição: dc.descriptionSão Paulo State University (UNESP) Medical School of Botucatu Laboratory of Immunopathology and Infectious Agents - LIAI UNIPEX - Experimental Research Unity, Sector 5, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Medical School of Botucatu Department of Pathology, SP-
Descrição: dc.descriptionMackenzie Evangelical School of Medicine Paraná–Curitiba-
Descrição: dc.descriptionHospital Geral de Curitiba - Exército Brasileiro - Curitiba-
Descrição: dc.descriptionLaboratory of Immunopathology Department of Clinical Pathology Federal University of Paraná-
Descrição: dc.descriptionSão Paulo State University (UNESP) Medical School of Botucatu Laboratory of Immunopathology and Infectious Agents - LIAI UNIPEX - Experimental Research Unity, Sector 5, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Medical School of Botucatu Department of Pathology, SP-
Descrição: dc.descriptionCAPES: 14/2019 - 88887-
Descrição: dc.descriptionFAPESP: 2018/09706-7-
Descrição: dc.descriptionCNPq: 313741/2021-2-
Descrição: dc.descriptionCNPq: 314288/2018-0-
Descrição: dc.descriptionCAPES: 371430/2019-00-
Descrição: dc.descriptionCAPES: 382141/2019-01-
Descrição: dc.descriptionCNPq: PPSUS 053/2021-
Idioma: dc.languageen-
Relação: dc.relationImmunobiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGlomerulonephritis-
Palavras-chave: dc.subjectNETs-
Palavras-chave: dc.subjectRaynaud's syndrome-
Palavras-chave: dc.subjectSLE-
Palavras-chave: dc.subjectSLEDAI-
Título: dc.titleAssociation of neutrophil extracellular trap levels with Raynaud's phenomenon, glomerulonephritis and disease index score in SLE patients from Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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