Prevalence of BRAF p.V600E and Detection Methods in Benign Mixed and Malignant Odontogenic Tumors: A Systematic Review

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Autor(es): dc.contributorUniversity of Pernambuco (UPE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIntegrated Anatomic Pathology Center–Hospital Universitário Oswaldo Cruz-
Autor(es): dc.contributorHospital Universitário Oswaldo Cruz-
Autor(es): dc.creatorSeverino-Lazo, Raisa Jordana Geraldine-
Autor(es): dc.creatorde Vasconcelos Carvalho, Marianne-
Autor(es): dc.creatorCampello, Camilla Porto-
Autor(es): dc.creatorMoraes, Sandra Lúcia Dantas-
Autor(es): dc.creatordo Egito Vasconcelos, Belmiro Cavalcanti-
Autor(es): dc.creatorPellizzer, Eduardo Piza-
Data de aceite: dc.date.accessioned2025-08-21T17:12:50Z-
Data de disponibilização: dc.date.available2025-08-21T17:12:50Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12105-023-01601-6-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301617-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301617-
Descrição: dc.descriptionBackground: The BRAF p.V600E genetic variant facilitates the pathogenesis of various tumors by triggering tumor proliferation and progression. The aim of this study was to analyze the prevalence of BRAF p.V600E in benign mixed epithelial and mesenchymal and malignant odontogenic tumors. In addition, we discussed the different detection methods used to assess for aberrant BRAF. Methods: This systematic review followed the PRISMA guidelines and was registered in Prospero (CRD42023445689). A comprehensive search of the PubMed/MEDLINE, Scopus, Web of Science, and Embase electronic databases was performed to answer the question “What is the prevalence of the BRAF p.V600E mutation in benign mixed and malignant odontogenic tumors?” The methodological quality of the selected studies was assessed using the JBI’s Critical Appraisal Tool. Results: Initially, 387 records were identified, but only 11 articles met the inclusion criteria. A total of 70 patients with benign mixed epithelial and mesenchymal odontogenic tumors and 63 with malignant odontogenic tumors were included in the analysis. We found that the BRAF p.V600E mutation had a prevalence of 31.42% in mixed tumors and 26.98% in malignant odontogenic tumors. Moreover, immunohistochemistry showed high concordance with DNA-based molecular methods. Conclusion: In general, the BRAF p.V600E variant exhibited a prominent prevalence in mixed and malignant odontogenic tumors. However, most of the findings are based on small cohorts of patients and further studies with larger cohorts are needed.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Pathology School of Dentistry University of Pernambuco (UPE)-
Descrição: dc.descriptionDepartment of Hebiatrics School of Dentistry University of Pernambuco (UPE)-
Descrição: dc.descriptionDepartment of Prosthodontics School of Dentistry University of Pernambuco (UPE)-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery School of Dentistry University of Pernambuco (UPE)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Dental School of Araçatuba São Paulo State University (UNESP)-
Descrição: dc.descriptionIntegrated Anatomic Pathology Center–Hospital Universitário Oswaldo Cruz, Rua Arnóbio Marquês, 310–Santo Amaro, PE-
Descrição: dc.descriptionHospital Universitário Oswaldo Cruz, Rua Arnóbio Marquês, 310–Santo Amaro, PE-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Dental School of Araçatuba São Paulo State University (UNESP)-
Formato: dc.format1000-1010-
Idioma: dc.languageen-
Relação: dc.relationHead and Neck Pathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBRAF V600E-
Palavras-chave: dc.subjectMalignant odontogenic tumor-
Palavras-chave: dc.subjectMixed odontogenic tumor-
Palavras-chave: dc.subjectOdontogenic tumors-
Título: dc.titlePrevalence of BRAF p.V600E and Detection Methods in Benign Mixed and Malignant Odontogenic Tumors: A Systematic Review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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