Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity Nilton Lins-
Autor(es): dc.contributorNilton Lins Foundation-
Autor(es): dc.contributorAmazonas State University-
Autor(es): dc.contributorInstituto Doutor Jose Frota Hospital-
Autor(es): dc.contributorUniversity of Fortaleza-
Autor(es): dc.contributorHospital Foundation of Hematology and Hemotherapy of Amazonas-
Autor(es): dc.creatorCavalcante, Joeliton S.-
Autor(es): dc.creatorde Almeida, Denis Emanuel Garcia-
Autor(es): dc.creatorSantos-Filho, Norival A.-
Autor(es): dc.creatorSartim, Marco Aurélio-
Autor(es): dc.creatorde Almeida Baldo, Amanda-
Autor(es): dc.creatorBrasileiro, Lisele-
Autor(es): dc.creatorAlbuquerque, Polianna L.-
Autor(es): dc.creatorOliveira, Sâmella S.-
Autor(es): dc.creatorSachett, Jacqueline Almeida Gonçalves-
Autor(es): dc.creatorMonteiro, Wuelton Marcelo-
Autor(es): dc.creatorFerreira, Rui Seabra-
Data de aceite: dc.date.accessioned2025-08-21T22:46:27Z-
Data de disponibilização: dc.date.available2025-08-21T22:46:27Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms241411508-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301610-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301610-
Descrição: dc.descriptionSnakebite envenoming represents a major health problem in tropical and subtropical countries. Considering the elevated number of accidents and high morbidity and mortality rates, the World Health Organization reclassified this disease to category A of neglected diseases. In Latin America, Bothrops genus snakes are mainly responsible for snakebites in humans, whose pathophysiology is characterized by local and systemic inflammatory and degradative processes, triggering prothrombotic and hemorrhagic events, which lead to various complications, organ damage, tissue loss, amputations, and death. The activation of the multicellular blood system, hemostatic alterations, and activation of the inflammatory response are all well-documented in Bothrops envenomings. However, the interface between inflammation and coagulation is still a neglected issue in the toxinology field. Thromboinflammatory pathways can play a significant role in some of the major complications of snakebite envenoming, such as stroke, venous thromboembolism, and acute kidney injury. In addition to exacerbating inflammation and cell interactions that trigger vaso-occlusion, ischemia–reperfusion processes, and, eventually, organic damage and necrosis. In this review, we discuss the role of inflammatory pathways in modulating coagulation and inducing platelet and leukocyte activation, as well as the inflammatory production mediators and induction of innate immune responses, among other mechanisms that are altered by Bothrops venoms.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology School of Agriculture Agronomic Sciences School São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionLaboratory of Bioprospection University Nilton Lins, Amazonas-
Descrição: dc.descriptionResearch & Development Department Nilton Lins Foundation, Amazonas-
Descrição: dc.descriptionGraduate Program in Tropical Medicine Department of Research Fundação de Medicina Tropical Dr. Heitor Vieira Dourado Amazonas State University, Amazonas-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionToxicological Information and Assistance Center Instituto Doutor Jose Frota Hospital, Ceará-
Descrição: dc.descriptionFaculty of Medicine University of Fortaleza, Ceará-
Descrição: dc.descriptionResearch Management Hospital Foundation of Hematology and Hemotherapy of Amazonas, Amazonas-
Descrição: dc.descriptionCenter for Translational Science and Development of Biopharmaceuticals FAPESP/CEVAP-UNESP, São Paulo-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology School of Agriculture Agronomic Sciences School São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionCenter for Translational Science and Development of Biopharmaceuticals FAPESP/CEVAP-UNESP, São Paulo-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP—Univ Estadual Paulista), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcomplement-
Palavras-chave: dc.subjecthemostasis-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectneutrophil-
Palavras-chave: dc.subjectplatelet-
Palavras-chave: dc.subjectsnake venom-
Palavras-chave: dc.subjectthromboinflammation-
Título: dc.titleCrosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology-
Tipo de arquivo: dc.typevídeo-
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