Type 2 diabetes mellitus in obesity promotes prolongation of cardiomyocyte contractile function, impaired Ca2+ handling and protein carbonylation damage

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Autor(es): dc.contributorFederal University of Espírito Santo-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCoelho, Priscila M.-
Autor(es): dc.creatorSimmer, Luísa M.-
Autor(es): dc.creatorda Silva, Daniel S.-
Autor(es): dc.creatordos Santos, Matheus C.-
Autor(es): dc.creatorKitagawa, Rodrigo R.-
Autor(es): dc.creatorPezzin, Mateus F.-
Autor(es): dc.creatorCorrea, Camila R.-
Autor(es): dc.creatorLeite, Jéssica G.-
Autor(es): dc.creatorLeopoldo, André S.-
Autor(es): dc.creatorLima-Leopoldo, Ana Paula-
Data de aceite: dc.date.accessioned2025-08-21T21:15:03Z-
Data de disponibilização: dc.date.available2025-08-21T21:15:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jdiacomp.2023.108559-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301601-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301601-
Descrição: dc.descriptionAims: To investigate whether the obesity associated to T2DM presented cardiomyocyte myocardial contractility dysfunction due to damage in Ca2+ handling, concomitantly with increased biomarkers of oxidative stress. Methods: Male Wistar rats were randomized into two groups: control (C): fed with standard diet; and obese (Ob) that fed a saturated high-fat. After the characterization of obesity (12 weeks), the Ob animals were submitted to T2DM induction with a single dose of intraperitoneal (i.p.) injection of streptozotocin (30 mg/kg). Thus, remained Ob rats that were characterized as to the presence (T2DMOb; n = 8) and/or absence (Ob; n = 10) of T2DM. Cardiac remodeling was measured by post-mortem morphological, isolated cardiomyocyte contractile function, as well as by intracellular Ca2+-handling analysis. Results: T2DMOb presented a significant reduction of all fat pads, total body fat and adiposity index. T2DMOb group presented a significant increase in protein carbonylation and superoxide dismutase (SOD) activity, respectively. T2DMOb promoted elevations in fractional shortening (15.6 %) and time to 50 % shortening (5.8 %), respectively. Time to 50 % Ca2+ decay was prolonged in T2DMOb, suggesting a possible impairment in Ca2+recapture and/or removal. Conclusion: Type 2 diabetes mellitus in obesity promotes prolongation of cardiomyocyte contractile function with protein carbonylation damage and impaired Ca2+ handling.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa e Inovação do Espírito Santo-
Descrição: dc.descriptionPostgraduate Program in Nutrition and Health Center of Health Sciences Federal University of Espírito Santo, Espírito Santo-
Descrição: dc.descriptionCenter of Health Sciences Department of Integrated Health Education Federal University of Espírito Santo, Espírito Santo-
Descrição: dc.descriptionDepartment of Sports Center of Physical Education and Sports Federal University of Espírito Santo, Espírito Santo-
Descrição: dc.descriptionPostgraduate Program in Physiological Sciences Center of Health Sciences Federal University of Espírito Santo, Espírito Santo-
Descrição: dc.descriptionCenter of Health Sciences Department of Pharmaceutical Sciences Federal University of Espírito Santo, Espírito Santo-
Descrição: dc.descriptionMedical School São Paulo State University (UNESP)-
Descrição: dc.descriptionMedical School São Paulo State University (UNESP)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa e Inovação do Espírito Santo: 2022-BT5CX-
Descrição: dc.descriptionFundação de Amparo à Pesquisa e Inovação do Espírito Santo: 74044958/16-
Idioma: dc.languageen-
Relação: dc.relationJournal of Diabetes and its Complications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCalcium handling-
Palavras-chave: dc.subjectContractile function-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectType 2 diabetes mellitus in obesity-
Título: dc.titleType 2 diabetes mellitus in obesity promotes prolongation of cardiomyocyte contractile function, impaired Ca2+ handling and protein carbonylation damage-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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