Synergistic activity between conventional antifungals and chalcone-derived compound against dermatophyte fungi and Candida spp.

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSchool of Medicine São José Do Rio Preto (FAMERP)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorMaschio-Lima, Taiza-
Autor(es): dc.creatorLemes, Thiago Henrique-
Autor(es): dc.creatorMarques, Mariela Domiciano Ribeiro-
Autor(es): dc.creatorSiqueira, João Paulo Zen-
Autor(es): dc.creatorde Almeida, Bianca Gottardo-
Autor(es): dc.creatorCaruso, Glaucia Rigotto-
Autor(es): dc.creatorVon Zeska Kress, Marcia Regina-
Autor(es): dc.creatorde Tarso da Costa, Paulo-
Autor(es): dc.creatorRegasini, Luis Octávio-
Autor(es): dc.creatorde Almeida, Margarete Teresa Gottardo-
Data de aceite: dc.date.accessioned2025-08-21T15:32:54Z-
Data de disponibilização: dc.date.available2025-08-21T15:32:54Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10123-024-00541-7-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301585-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301585-
Descrição: dc.descriptionThe scarce antifungal arsenal, changes in the susceptibility profile of fungal agents, and lack of adherence to treatment have contributed to the increase of cases of dermatomycoses. In this context, new antimicrobial substances have gained importance. Chalcones are precursors of the flavonoid family that have multiple biological activities, have high tolerability by humans, and easy synthesis. In this study, we evaluated the in vitro antifungal activity, alone and in combination with conventional antifungal drugs, of the VS02–4′ethyl chalcone-derived compound against dermatophytes and Candida spp. Susceptibility testing was carried out by broth microdilution. Experiments for determination of the target of the compound on the fungal cell, time-kill kinetics, and toxicity tests in Galleria mellonella model were also performed. Combinatory effects were evaluated by the checkerboard method. Results showed high activity of the compound VS02–4′ethyl against dermatophytes (MIC of 7.81–31.25 μg/ml). The compound targeted the cell membrane, and the time-kill test showed the compound continues to exert gradual activity after 5 days on dermatophytes, but no significant activity on Candida. Low toxicity was observed at 250 mg/kg. Excellent results were observed in the combinatory test, where VS02–4′ethyl showed synergistic interactions with itraconazole, fluconazole, terbinafine, and griseofulvin, against all isolates tested. Although further investigation is needed, these results revealed the great potential of chalcone-derived compounds against fungal infections for which treatments are long and laborious.-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São José do Rio Preto-
Descrição: dc.descriptionDepartment of Dermatological Infectious and Parasitic Diseases School of Medicine São José Do Rio Preto (FAMERP), São José do Rio Preto-
Descrição: dc.descriptionEmbrapa Instrumentation-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP), Ribeirão Preto-
Descrição: dc.descriptionLaboratory of Antibiotics and Chemotherapy Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São José do Rio Preto-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São José do Rio Preto-
Descrição: dc.descriptionLaboratory of Antibiotics and Chemotherapy Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São José do Rio Preto-
Formato: dc.format265-275-
Idioma: dc.languageen-
Relação: dc.relationInternational Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal activity-
Palavras-chave: dc.subjectCandida-
Palavras-chave: dc.subjectChalcones-
Palavras-chave: dc.subjectDermatomycoses-
Palavras-chave: dc.subjectDermatophytes-
Palavras-chave: dc.subjectSynergistic interaction-
Título: dc.titleSynergistic activity between conventional antifungals and chalcone-derived compound against dermatophyte fungi and Candida spp.-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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