Carnosine supplementation and retinal oxidative parameters in a high-calorie diet rat model

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCentro Oftalmologico de Curitiba-
Autor(es): dc.contributorHospital Angelina Caron-
Autor(es): dc.contributorPontificia Universidade Catolica Do Paraná-
Autor(es): dc.contributorUniversità Degli Studi Di Milano-
Autor(es): dc.creatorde Almeida Torres, Rogil Jose-
Autor(es): dc.creatorMoreto, Fernando-
Autor(es): dc.creatorLuchini, Andrea-
Autor(es): dc.creatorde Almeida Torres, Rogerio Joao-
Autor(es): dc.creatorLongo, Sofia Pimentel-
Autor(es): dc.creatorPinho, Ricardo Aurino-
Autor(es): dc.creatorNagashima, Seigo-
Autor(es): dc.creatorde Noronha, Lucia-
Autor(es): dc.creatorFerron, Artur Junio Togneri-
Autor(es): dc.creatorde Almeida Silva, Carol Cristina Vagula-
Autor(es): dc.creatorCorrea, Camila Renata-
Autor(es): dc.creatorAldini, Giancarlo-
Autor(es): dc.creatorFerreira, Ana Lucia Anjos-
Data de aceite: dc.date.accessioned2025-08-21T17:16:00Z-
Data de disponibilização: dc.date.available2025-08-21T17:16:00Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12886-023-03255-y-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301557-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301557-
Descrição: dc.descriptionBackground: To assess oxidative effects induced by a high-calorie diet on the retina of Wistar rats and test the antioxidative effects of carnosine supplementation. Methods: Wistar rats were randomly divided into the following groups: standard diet (SD), high-calorie diet (HcD), standard diet + carnosine (SD + Car), and high-calorie diet + carnosine (HcD + Car). The body weight, adiposity index, plasma glucose, total lipids, high-density lipoprotein (HDL), low-density lipoprotein (LDL), uric acid, creatinine, and triglycerides of the animals were evaluated. The retinas were analyzed for markers of oxidative stress. Hydrogen peroxide production was assessed by 2',7'-dichlorodihydrofluorescein diacetate (DCF) oxidation. The total glutathione (tGSH), total antioxidant capacity (TAC), protein carbonyl, and sulfhydryl groups of the antioxidant system were analyzed. Results: TAC levels increased in the retinas of the SD + Car group compared to the SD group (p < 0.05) and in the HcD + Car group compared to the HcD group (p < 0.05). The levels of GSH and the GSSH:GSSG ratio were increased in the HcD + Car group compared to the SD + Car group (p < 0.05). An increase in the retinal carbonyl content was observed in the HcD group compared to the SD group (p < 0.05) and in the HcD + Car group compared to the SD + Car group (p < 0.05). A high-calorie diet (HcD) was also associated with a decrease in retinal sulfhydryl-type levels compared to the SD group (p < 0.05). Conclusion: The results suggest that feeding a high-calorie diet to rats can promote an increase in carbonyl content and a reduction in sulfhydryl groups in their retinas. The administration of carnosine was not effective in attenuating these oxidative markers. Trial registration: Animal Ethics Committee of Botucatu Medical School - Certificate number 1292/2019.-
Descrição: dc.descriptionMedical School Department of Internal Medicine Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartment of Ophthalmology Centro Oftalmologico de Curitiba, PR-
Descrição: dc.descriptionDepartment of Ophthalmology Hospital Angelina Caron, PR-
Descrição: dc.descriptionPostgraduate Program in Health Sciences School of Medicine Pontificia Universidade Catolica Do Paraná, PR-
Descrição: dc.descriptionDipartimento Di Scienze Farmaceutiche (DISFARM) Università Degli Studi Di Milano-
Descrição: dc.descriptionMedical School Department of Internal Medicine Universidade Estadual Paulista (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationBMC Ophthalmology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectCarnosine-
Palavras-chave: dc.subjectHigh-calorie diet-
Palavras-chave: dc.subjectRetina-
Título: dc.titleCarnosine supplementation and retinal oxidative parameters in a high-calorie diet rat model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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