Review of the comparative pathological and immunohistochemical features of human and canine cutaneous melanocytic neoplasms

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPaulista University-
Autor(es): dc.contributorUniversity Center of Adamantina-
Autor(es): dc.contributorMedical School-
Autor(es): dc.creatorContel, Isabeli J.-
Autor(es): dc.creatorFonseca-Alves, Carlos E.-
Autor(es): dc.creatorFerrari, Heitor F.-
Autor(es): dc.creatorLaufer-Amorim, Renee-
Autor(es): dc.creatorXavier-Júnior, José C.C.-
Data de aceite: dc.date.accessioned2025-08-21T16:38:10Z-
Data de disponibilização: dc.date.available2025-08-21T16:38:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jcpa.2024.04.001-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301546-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301546-
Descrição: dc.descriptionMelanocytic neoplasms originate from melanocytes and melanoma, the malignant form, is a common canine neoplasm and the most aggressive human skin cancer. Despite many similarities between these neoplasms in both species, only a limited number of studies have approached these entities in a comparative manner. Therefore, this review compares benign and malignant melanocytic neoplasms in dogs and humans, exclusively those arising in the haired skin, with regard to their clinicopathological, immunohistochemical and molecular aspects. Shared features include spontaneous occurrence, macroscopic features and microscopic findings when comparing human skin melanoma in the advanced/invasive stage and canine cutaneous melanoma, immunohistochemical markers and several histopathological prognostic factors. Differences include the apparent absence of active mutations in the BRAF gene in canine cutaneous melanoma and less aggressive clinical behaviour in dogs than in humans. Further studies are required to elucidate the aetiology and genetic development pathways of canine cutaneous melanocytic neoplasms. Evaluation of the applicability of histopathological prognostic parameters commonly used in humans for dogs are also needed. The similarities between the species and the recent findings regarding genetic mutations in canine cutaneous melanomas suggest the potential utility of dogs as a natural model for human melanomas that are not related to ultraviolet radiation.-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University, Av. Prof. Mário R. Guimarães Montenegro, s/n, Campus Botucatu, SP-
Descrição: dc.descriptionInstitute of Health Sciences Paulista University, Rua Luiz Levorato, 140, Jardim Marabá, SP-
Descrição: dc.descriptionUniversity Center of Adamantina, Rua Nove de Julho, 730, Centro, SP-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University, Rua Prof. Doutor Walter Mauricio Correa, s/n, Campus de Botucatu, SP-
Descrição: dc.descriptionSalesian Catholic University Center Auxilium Medical School, Rod. Sen. Teotônio Vilela, 3821, Jardim Alvorada, SP-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University, Av. Prof. Mário R. Guimarães Montenegro, s/n, Campus Botucatu, SP-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University, Rua Prof. Doutor Walter Mauricio Correa, s/n, Campus de Botucatu, SP-
Formato: dc.format26-35-
Idioma: dc.languageen-
Relação: dc.relationJournal of Comparative Pathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdogs-
Palavras-chave: dc.subjecthumans-
Palavras-chave: dc.subjectimmunohistochemistry-
Palavras-chave: dc.subjectmelanocytes-
Palavras-chave: dc.subjectmelanoma-
Palavras-chave: dc.subjectprognosis-
Palavras-chave: dc.subjectskin neoplasm-
Título: dc.titleReview of the comparative pathological and immunohistochemical features of human and canine cutaneous melanocytic neoplasms-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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