Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats

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Autor(es): dc.contributorUNOESTE-
Autor(es): dc.contributorTexas A&M University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorNorthern University of Paraná-
Autor(es): dc.creatorD’Almeida, Thaynara Zanoni-
Autor(es): dc.creatorGomes, Mariana Janini-
Autor(es): dc.creatorEngel, Leticia Estevam-
Autor(es): dc.creatorGiometti, Ines Cristina-
Autor(es): dc.creatorFerreira, Natalia Zamberlan-
Autor(es): dc.creatorStuani, Rafael-
Autor(es): dc.creatorCorrêa, Camila Renata-
Autor(es): dc.creatorCastoldi, Robson Chacon-
Autor(es): dc.creatorNunes, Sarah Gomes-
Autor(es): dc.creatorAguiar, Andreo Fernando-
Autor(es): dc.creatorCastilho, Anthony César-
Autor(es): dc.creatorOkoshi, Marina Politi-
Autor(es): dc.creatorPacagnelli, Francis Lopes-
Data de aceite: dc.date.accessioned2025-08-21T20:34:46Z-
Data de disponibilização: dc.date.available2025-08-21T20:34:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0316441-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301543-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301543-
Descrição: dc.descriptionAim To investigate whether high-intensity interval training (HIIT) improves physical performance, systolic blood pressure, and markers of oxidative stress and inflammation in skeletal muscle of spontaneously hypertensive rats (SHR). Methods Nineteen male SHR rats were randomly assigned to two groups: sedentary (SHRC) and trained (SHR+T). The SHR+T group trained five times a week for eight weeks on a treadmill, while the SHR group remained without any exercise stimulus throughout the experimental period. Maximum physical performance and systolic blood pressure (SBP) were assessed before and after the training period. The following variables were measured in the tibialis anterior (TA) muscle: gene expression of the NADPH oxidase complex (NOX2, NOX4, p22phox, p47phox) and the NF-kB pathway (NF-kB and Ik-B), lipid peroxidation (malonaldehyde; MDA), protein carbonylation, hydrophilic antioxidant capacity (HAC) and pro-inflammatory cytokines (IL-6 and TNF-α). Results SHR+T rats showed higher physical performance and levels of IL-6, and lower SBP and protein carbonylation (p<0.05), compared with SHRC rats. No significant differences (p>0.05) were observed in the other variables. Significance Our results indicate that HIIT is an effective non-pharmacologic strategy to improve physical performance, reduce SBP, and modulate the skeletal muscle oxidative damage and inflammation in hypertensive rats.-
Descrição: dc.descriptionPostgraduate Program in Animal Science UNOESTE-
Descrição: dc.descriptionDepartment of Kinesiology and Sports Management Texas A&M University-
Descrição: dc.descriptionPostgraduate Program in Health Science UNOESTE-
Descrição: dc.descriptionBotucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences Júlio de Mesquita Filho Paulista State University, São Paulo-
Descrição: dc.descriptionPostgraduate Program in Physical Exercise in Health Promotion Northern University of Paraná-
Descrição: dc.descriptionBotucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences Júlio de Mesquita Filho Paulista State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleEffects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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