Unusual Differences in the Pulmonary Histopathology of Mice after Intranasal Infection with Mycelial Propagules of Histoplasma capsulatum Strains Classified as LAm A2 and NAm 2 Phylogenetic Species

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Autor(es): dc.contributorUniversidad Nacional Autónoma de México (UNAM)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPulido-Camarillo, Evelyn-
Autor(es): dc.creatorSahaza, Jorge H.-
Autor(es): dc.creatorde Souza Pitangui, Nayla-
Autor(es): dc.creatorMendes-Giannini, Maria José S.-
Autor(es): dc.creatorFusco-Almeida, Ana M.-
Autor(es): dc.creatorPérez-Torres, Armando-
Autor(es): dc.creatorTaylor, Maria Lucia-
Data de aceite: dc.date.accessioned2025-08-21T23:28:55Z-
Data de disponibilização: dc.date.available2025-08-21T23:28:55Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof9100974-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301511-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301511-
Descrição: dc.descriptionThe ascomycete Histoplasma capsulatum is the causative agent of systemic respiratory mycosis histoplasmosis, which sometimes develops acute disseminated or chronic clinical forms, with the latter usually associated with granuloma formation. The present report shows differential histopathological changes in the pulmonary inflammatory response of mice infected intranasally with the mycelial morphotype of H. capsulatum strains with distinct genotypes, EH-46 and G-217B, classified as LAm A2 and NAm 2 phylogenetic species, respectively. Infected male BALB/c mice were sacrificed at different postinfection times, and their serial lung sections were stained with periodic acid–Schiff and analyzed via microscopy. In mice infected with the LAm A2 strain, the results showed progressive changes in the inflammatory infiltrate of the lung parenchyma during the first hours and days postinfection as well as granulomas with macrophages containing intracellular yeast cells, which prevailed at 14 and 21 days postinfection. Bronchiolar-associated lymphoid tissue was induced in mice infected with both strains, primarily in mice infected with the NAm 2 strain. Several lung sections from mice infected with the LAm A2 strain showed PAS-positive yeast cells aggregated in a perinuclear crown-like arrangement in macrophages from 3 h to 21 days postinfection. These findings highlight differences in the host pulmonary inflammatory response associated with distinct H. capsulatum species.-
Descrição: dc.descriptionDepartamento de Biología Celular y Tisular Facultad de Medicina Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, Circuito Escolar s/n, Ciudad Universitaria-
Descrição: dc.descriptionUnidad de Micología Departamento de Microbiología y Parasitología Facultad de Medicina Universidad Nacional Autónoma de México (UNAM)-
Descrição: dc.descriptionDepartamento de Biología Celular e Molecular Faculdade de Medicina Universidade de São Paulo, São Paulo-
Descrição: dc.descriptionDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP), São Paulo-
Descrição: dc.descriptionDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbronchiolar-associated lymphoid tissue-
Palavras-chave: dc.subjectgranuloma-
Palavras-chave: dc.subjectHistoplasma genotypes-
Palavras-chave: dc.subjectpneumonia-
Palavras-chave: dc.subjectpulmonary response-
Título: dc.titleUnusual Differences in the Pulmonary Histopathology of Mice after Intranasal Infection with Mycelial Propagules of Histoplasma capsulatum Strains Classified as LAm A2 and NAm 2 Phylogenetic Species-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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