Alginate-cysteine conjugate: antimicrobial hydrogel from natural source

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Araraquara-UNIARA-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorScience and Technology of São Paulo-
Autor(es): dc.creatorSoares, Tatiane Araujo-
Autor(es): dc.creatorTorres, André Henrique Furtado-
Autor(es): dc.creatorDorm, Bruna Carolina-
Autor(es): dc.creatorAmaral, André Capaldo-
Autor(es): dc.creatorde Souza Nossa, Tamires-
Autor(es): dc.creatorTrovatti, Eliane-
Data de aceite: dc.date.accessioned2025-08-21T19:59:56Z-
Data de disponibilização: dc.date.available2025-08-21T19:59:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10965-024-04178-y-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301507-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301507-
Descrição: dc.descriptionMicrobial infections spreading represents a challenging scenario worldwide, with remarkable demand for attention in food and heath fields. An increase in studies for the development of new biomaterials with the aim of decreasing or avoiding bacterial infections has been arising, and the natural polymers have been the focus of some studies. Alginate is an abundant natural polymer with potential for chemical modifications based on its chemical structure and, to the best of our knowledge, it was not modified for antimicrobial activity. This study aims to prepare a new biomaterial by chemical modification of alginate coupled with the cysteine, aiming to infer intrinsic antimicrobial activity to the resulting material, and also, situ gelation capability by the formation of disulfide bonds. The polymers were characterized by FTIR, NMR, thermal analysis, cross-linking test, rheological analysis, hydrolytic degradation, microbiological test (against E. coli and S. aureus) and cytotoxicity. The results of the chemical characterization, as evidenced by FTIR and NMR, indicated the success of the reaction and the increase in the viscosity of alginate-Cys due to the cross-linking of the material. The results showed no toxicity and demonstrated antimicrobial activity against the studied bacteria, indicating their potential for the development of materials for applications in the confection and coating of medical devices, aiming to decrease or avoid infections.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniversity of Araraquara-UNIARA, Rua Carlos Gomes, 1217, SP-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry - São Paulo State University (UNESP) Institute of Chemistry, SP-
Descrição: dc.descriptionLaboratory of Materials (LabMat) and Laboratory of Biopolymers (LaBioPol) Federal Institute of Education Science and Technology of São Paulo, Av. João Olímpio de Oliveira, 1561, SP-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry - São Paulo State University (UNESP) Institute of Chemistry, SP-
Descrição: dc.descriptionFAPESP: 2017-18782-6-
Descrição: dc.descriptionCAPES: 88870713632/2022-00-
Idioma: dc.languageen-
Relação: dc.relationJournal of Polymer Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlginate-
Palavras-chave: dc.subjectAntimicrobial activity-
Palavras-chave: dc.subjectCysteine-
Palavras-chave: dc.subjectE. Coli-
Palavras-chave: dc.subjectS.aureus-
Título: dc.titleAlginate-cysteine conjugate: antimicrobial hydrogel from natural source-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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