Combined physical exercise re-synchronizes expression of Bmal1 and REV-ERBα and up-regulates apoptosis and metabolism in the prostate during aging

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorTavares, Maria Eduarda Almeida-
Autor(es): dc.creatorPinto, Ana Paula-
Autor(es): dc.creatorda Rocha, Alisson Luiz-
Autor(es): dc.creatorSampaio, Larissa Victorino-
Autor(es): dc.creatorCorreia, Rafael Ribeiro-
Autor(es): dc.creatorBatista, Victor Rogério Garcia-
Autor(es): dc.creatorVeras, Allice Santos Cruz-
Autor(es): dc.creatorChaves-Neto, Antonio Hernandes-
Autor(es): dc.creatorda Silva, Adelino Sanchez Ramos-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo-
Data de aceite: dc.date.accessioned2025-08-21T16:33:24Z-
Data de disponibilização: dc.date.available2025-08-21T16:33:24Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2024.122800-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301486-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301486-
Descrição: dc.descriptionBackground: Aging increases the prevalence of prostate cancer. The circadian clock coordinates metabolism, cell cycle, and tumor suppressor p53. Although physical exercise has several effects on preventing prostate diseases, its effect on regulating genes and proteins of the circadian rhythm of the prostate needs to be better evaluated. The present study verified expression of REV-ERBα (Nr1d1), Bmal1, apoptosis, tumor suppressors, energetic metabolism markers, and androgen receptors in the prostatic microenvironment in 18-month-old mice submitted to combined physical training. Methods: C57BL/6 J mice were divided into 2 groups: 6 months-old (n = 10) and 18 months-old, (n = 20). The 18-month-old animals were divided into 2 subgroups: sedentary (n = 10, 18 m Sed) and submitted to combined physical training (n = 10, 18 m TR). Combined physical training protocol was performed by running on the treadmill (40–60 % of incremental load test) and climbing strength training (40–50 % of maximum repetition test), consisting of 5×/week (3 days aerobic and 2 days strength) for 3 weeks. The prostate was prepared for Western blot and RT-qPCR analysis, and the plasm was prepared for the biochemistry analysis. Results: Combined physical exercise during aging led to increased levels of Bmal1 and decreased levels of REV-ERBα in the prostate. These results were accompanied by a reduction in the AMPK/SIRT1/PGC-1α proteins and an increase in the PI3K/AKT and p53/PTEN/caspase 3 pathways, promoting apoptotic potential. Conclusion: These findings suggest that strength and aerobic physical exercise may be preventive in the development of preneoplastic molecular alterations and age-related features by re-synchronizes Bmal1 and REV-ERBα in prostatic tissues.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Physical Education São Paulo State University (UNESP) School of Technology and Sciences, SP-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP), SP-
Descrição: dc.descriptionPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionSchool of Applied Sciences University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionDepartment of Physical Education São Paulo State University (UNESP) School of Technology and Sciences, SP-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2019/11820-5-
Descrição: dc.descriptionFAPESP: 2020/16310-2-
Descrição: dc.descriptionFAPESP: 2021/06291-3-
Descrição: dc.descriptionFAPESP: 2022/06807-2-
Descrição: dc.descriptionCNPq: 306492/2021-0-
Descrição: dc.descriptionCNPq: 308999/2022-3-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAMPK/SIRT1-
Palavras-chave: dc.subjectNr1d1-
Palavras-chave: dc.subjectPI3K/AKT-
Palavras-chave: dc.subjectPTEN and Bmal1-
Palavras-chave: dc.subjectSenescence-
Título: dc.titleCombined physical exercise re-synchronizes expression of Bmal1 and REV-ERBα and up-regulates apoptosis and metabolism in the prostate during aging-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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