Novel Bidentate Amine Ligand and the Interplay between Pd(II) and Pt(II) Coordination and Biological Activity

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversity of Leeds-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatorOliveira, Laiane S.-
Autor(es): dc.creatorRosa, Letícia B.-
Autor(es): dc.creatorAffonso, Daniele D.-
Autor(es): dc.creatorSantos, Igor A.-
Autor(es): dc.creatorDa Silva, Jennyfer C.-
Autor(es): dc.creatorRodrigues, Gustavo C.-
Autor(es): dc.creatorHarris, Mark-
Autor(es): dc.creatorJardim, Ana Carolina G.-
Autor(es): dc.creatorNakahata, Douglas H.-
Autor(es): dc.creatorSabino, José R.-
Autor(es): dc.creatorde Carvalho, João E.-
Autor(es): dc.creatorMiguel, Danilo C.-
Autor(es): dc.creatorRuiz, Ana Lucia T. G.-
Autor(es): dc.creatorAbbehausen, Camilla-
Data de aceite: dc.date.accessioned2025-08-21T21:13:17Z-
Data de disponibilização: dc.date.available2025-08-21T21:13:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/cbic.202300696-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301484-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301484-
Descrição: dc.descriptionPt(II) and Pd(II) coordinating N-donor ligands have been extensively studied as anticancer agents after the success of cisplatin. In this work, a novel bidentate N-donor ligand, the N-[[4-(phenylmethoxy)phenyl]methyl]-2-pyridinemethanamine, was designed to explore the antiparasitic, antiviral and antitumor activity of its Pt(II) and Pd(II) complexes. Chemical and spectroscopic characterization confirm the formation of [MLCl2] complexes, where M=Pt(II) and Pd(II). Single crystal X-ray diffraction confirmed a square-planar geometry for the Pd(II) complex. Spectroscopic characterization of the Pt(II) complex suggests a similar structure. 1H NMR, 195Pt NMR and HR-ESI-MS(+) analysis of DMSO solution of complexes indicated that both compounds exchange the chloride trans to the pyridine for a solvent molecule with different reaction rates. The ligand and the two complexes were tested for in vitro antitumoral, antileishmanial, and antiviral activity. The Pt(II) complex resulted in a GI50 of 10.5 μM against the NCI/ADR-RES (multidrug-resistant ovarian carcinoma) cell line. The ligand and the Pd(II) complex showed good anti-SARS-CoV-2 activity with around 65 % reduction in viral replication at a concentration of 50 μM.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstitute of Chemistry University of Campinas, Cidade Universitária Zeferino Vaz – Barão Geraldo, Campinas-
Descrição: dc.descriptionInstitute of Biology University of Campinas Cidade Universitária Zeferino Vaz –, Barão Geraldo, Campinas-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences University of Campinas Cidade Universitária Zeferino Vaz –, Barão Geraldo, Campinas-
Descrição: dc.descriptionInstitute of Biomedical Sciences Federal University of Uberlândia, João Naves de Ávila Avenue, Minas Gerais-
Descrição: dc.descriptionSchool of Molecular and Cellular Biology Faculty of Biological Sciences University of Leeds, Woodhouse-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University, Cristóvão Colombo street, Jardim Nazareth. São José do Rio Preto-
Descrição: dc.descriptionInstitute of Chemistry Federal University of Goiás, Esperança Avenue, Campus Samambaia., Goiás-
Descrição: dc.descriptionInstitute of Physics Federal University of Goiás, Esperança Avenue, Campus Samambaia., Goiás-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University, Cristóvão Colombo street, Jardim Nazareth. São José do Rio Preto-
Descrição: dc.descriptionCNPq: #313440/2019-0-
Descrição: dc.descriptionCNPq: #429463/2018-9-
Idioma: dc.languageen-
Relação: dc.relationChemBioChem-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantioxidant-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectPalladium-
Palavras-chave: dc.subjectPlatinum-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleNovel Bidentate Amine Ligand and the Interplay between Pd(II) and Pt(II) Coordination and Biological Activity-
Tipo de arquivo: dc.typelivro digital-
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