Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs

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Autor(es): dc.contributorVetCancer Veterinary Oncology-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorVCLab Pathology-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorInstituto Universitario de Ciencias de la Salud. Fundación Barceló-CONICET-
Autor(es): dc.creatorRangel, Marcelo Monte Mor-
Autor(es): dc.creatorLinhares, Laís Calazans Menescal-
Autor(es): dc.creatorde Oliveira, Krishna Duro-
Autor(es): dc.creatorSuzuki, Daniela Ota Hisayasu-
Autor(es): dc.creatorMaglietti, Felipe Horacio-
Autor(es): dc.creatorde Nardi, Andrigo Barboza-
Data de aceite: dc.date.accessioned2025-08-21T15:53:06Z-
Data de disponibilização: dc.date.available2025-08-21T15:53:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-023-45433-4-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301480-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301480-
Descrição: dc.descriptionLocal treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures. This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC. This prospective study included 21 dogs with spontaneous bladder UC. Regional/distant metastases and neoplastic infiltration of the serosa was considered the main exclusion criteria. We had no deaths during ECT or in the immediate postoperative period, and no suture dehiscence. Most dogs (19/21) developed mild adverse effects, whereas two dogs developed ureteral stenosis. Complete response (CR) was achieved in 62% of the cases (13/21), while partial response (PR) was achieved in 24% (5/21). The median survival and disease-free survival times were 284 and 270 days, respectively. Overall survival was significantly better in the dogs who achieved a CR. In conclusion, ECT was well-tolerated in dogs with UC, demonstrating its safety and feasibility. These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionVetCancer Veterinary Oncology, São Paulo-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP) “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionVCLab Pathology, São Paulo-
Descrição: dc.descriptionInstitute of Biomedical Engineering Federal University of Santa Catarina (UFSC), Santa Catarina-
Descrição: dc.descriptionInstituto Universitario de Ciencias de la Salud. Fundación Barceló-CONICET-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP) “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionCAPES: 88887.706252/2022-00-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleEvaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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