Depth of invasion analysis to predict acral melanoma outcomes

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorThe Federal University of Mato Grosso do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAmaral Carvalho Hospital-
Autor(es): dc.contributorCentro Universitário Unisalesiano Auxilium-
Autor(es): dc.contributorPathology Institute of Araçatuba-
Autor(es): dc.creatorAsato, Marcel Arakaki-
Autor(es): dc.creatorMoares-Neto, Francisco Alves-
Autor(es): dc.creatorde Toledo Moraes, Marcelo Padovani-
Autor(es): dc.creatorOcanha-Xavier, Juliana Polizel-
Autor(es): dc.creatorTakita, Luiz Carlos-
Autor(es): dc.creatorMarques, Mariangela Esther Alencar-
Autor(es): dc.creatorXavier-Júnior, José Cândido Caldeira-
Data de aceite: dc.date.accessioned2025-08-21T23:38:49Z-
Data de disponibilização: dc.date.available2025-08-21T23:38:49Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.anndiagpath.2024.152305-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301476-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301476-
Descrição: dc.descriptionBackground: Acral melanoma is a subtype with worse outcomes. The Breslow micrometric measurement is the most critical parameter in planning treatment and predicting outcomes. However, for acral lentiginous melanoma, the value of the Breslow thickness is a matter of debate. Depth of Invasion (DOI) is a well-established measure for staging oral squamous cell carcinoma. Objective: This study compared DOI and Breslow thickness for predicting acral melanoma outcomes. Methods: We performed a retrospective cross-sectional study of 71 acral melanoma lesions subjected to sentinel lymph node biopsy at one Brazilian referral center. Results: Cox model univariate analysis showed that both DOI and Breslow thickness predicted melanoma specific survival (HR 1.12; p = 0.0255 and HR 1.144; p = 0.0006, respectively), although Kaplan Meier curve was only significant for Breslow (χ2 = 5.792; p = 0.0161) and not for DOI (χ2 = 0.2556; p = 0.6132). Sentinel lymph node status and presence or absence of ulceration also predicted specific survival in patients with acral melanoma (χ2 = 6.3514; p = 0.0117 and χ2 = 4.2793; p = 0.0386, respectively). Multivariate analysis, however, demonstrated that Breslow depth was the only independent parameter for predicting acral melanoma specific survival (HR 1.144; p = 0.0006). Conclusion: Even though Breslow thickness remains the main predictor for survival in acral melanoma, it is not a perfect parameter. The introduction of DOI in this context opens new perspectives for predicting acral melanoma outcomes.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Medicine The Federal University of Mato Grosso do Sul-
Descrição: dc.descriptionSchool of Medicine São Paulo State University, SP-
Descrição: dc.descriptionAmaral Carvalho Hospital, SP-
Descrição: dc.descriptionSchool of Medicine Centro Universitário Unisalesiano Auxilium, SP-
Descrição: dc.descriptionPathology Institute of Araçatuba, SP-
Descrição: dc.descriptionSchool of Medicine São Paulo State University, SP-
Descrição: dc.descriptionFAPESP: 2021/09431-0-
Idioma: dc.languageen-
Relação: dc.relationAnnals of Diagnostic Pathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMelanoma-
Palavras-chave: dc.subjectNeoplasm staging-
Palavras-chave: dc.subjectPathology-
Palavras-chave: dc.subjectSkin neoplasms-
Título: dc.titleDepth of invasion analysis to predict acral melanoma outcomes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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