Dual-action microparticles for ulcerative colitis: Cellulose nanofibers-enhanced delivery of 5-ASA and probiotics

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Católica de Santa María-
Autor(es): dc.creatorLopes, Sílvio André-
Autor(es): dc.creatorCardoso, Vinicius Martinho Borges-
Autor(es): dc.creatorRoque-Borda, Cesar Augusto-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Data de aceite: dc.date.accessioned2025-08-21T18:14:41Z-
Data de disponibilização: dc.date.available2025-08-21T18:14:41Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2024.139060-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301457-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301457-
Descrição: dc.descriptionUlcerative colitis (UC) is a chronic inflammatory bowel disease initially treated with mesalazine (5-ASA). However, its effectiveness is limited by rapid absorption, low colonic concentration, and exacerbation of dysbiosis. Probiotics can mitigate dysbiosis if they survive the acidic conditions of the stomach. In this study, colon-specific microparticles (MPs) based on RS/P and reinforced with cellulose nanofibers (CNF) were used to co-encapsulate 5-ASA and L. rhamnosus. MPs prepared by spray-drying demonstrated a spherical shape, with sizes ranging from 1 to 10 μm, high encapsulation efficiency (up to 81.5 %), and maintenance of L. rhamnosus viability (5.74 log CFU/g of sample) even after 30 days of storage at 4 °C. Differential scanning calorimetry indicated a reduction in the melting peak of 5-ASA after microencapsulation, suggesting a decrease in its crystallinity. The samples also exhibited high mucoadhesivity, with the presence of CNF significantly increasing the speed of establishing interactions with mucin. In vitro release profiles showed lower release rates in acidic media, resulting in the majority of 5-ASA being released in intestinal and colonic media. These MPs represent a promising strategy for promoting specific release in the colon, minimizing side effects associated with conventional treatment, and potentially improving therapeutic efficacy in the context of UC.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionVicerrectorado de Investigación Universidad Católica de Santa María-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2023/04633-0-
Descrição: dc.descriptionCNPq: 402105/2023-0-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCellulose nanofibers-
Palavras-chave: dc.subjectCo-delivery-
Palavras-chave: dc.subjectcolon-specific release-
Palavras-chave: dc.subjectMicroparticles-
Palavras-chave: dc.subjectProbiotics-
Palavras-chave: dc.subjectUlcerative colitis-
Título: dc.titleDual-action microparticles for ulcerative colitis: Cellulose nanofibers-enhanced delivery of 5-ASA and probiotics-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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