Novel renal injury markers in dogs with ehrlichiosis

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Autor(es): dc.contributorNorth Carolina State University - NCSU-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIDEXX Laboratories Inc.-
Autor(es): dc.contributorAbbott Diagnostics Inc.-
Autor(es): dc.creatorLe Sueur, André N.V.-
Autor(es): dc.creatorde Souza, Adriana A.L.-
Autor(es): dc.creatorPaes, Antonio C.-
Autor(es): dc.creatorTakahira, Regina K.-
Autor(es): dc.creatorMelchert, Alessandra-
Autor(es): dc.creatorOkamoto, Adriano S.-
Autor(es): dc.creatorCoyne, Michael-
Autor(es): dc.creatorMurphy, Rachel-
Autor(es): dc.creatorSzlosek, Donald-
Autor(es): dc.creatorPeterson, Sarah-
Autor(es): dc.creatorGuimarães-Okamoto, Priscylla T.C.-
Data de aceite: dc.date.accessioned2025-08-21T23:31:28Z-
Data de disponibilização: dc.date.available2025-08-21T23:31:28Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0293545-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301452-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301452-
Descrição: dc.descriptionCanine monocytic ehrlichiosis (CME) has been observed to impact renal function. Currently, the recognition of acute kidney injury is through the nonspecific biomarker serum creatinine (sCr). Novel markers of renal injury such as urinary clusterin (uClust) and urinary cystatin B (uCysB) may increase our understanding of the relationship between ehrlichiosis and renal cellular injury. The aim of this study was to evaluate novel renal injury biomarkers in dogs with acute CME. Twenty healthy dogs were enrolled in the control group (CG), and 16 dogs naturally infected with Ehrlichia canis were included in the Ehrlichia Group (EG). All dogs were followed for 45 days. EG dogs were treated with doxycycline twice daily for the first 30 days. Urine and serum were collected at: 0, 0.5, 1, 15, 30, and 45 days after start of treatment. Urine concentrations of uClust and uCysB were determined using a research ELISA immunoassay. A linear mixed model was used to estimate population mean of renal injury markers with patient as the random effect, and day and treatment as fixed effects. EG was observed to have higher uClust values compared to CG (estimated population mean EG: 213 ng/dL vs. CG: 84 ng/dL, P < 0.001). EG was observed to have higher uCysB values compared to CG (estimated population mean EG: 248 ng/dL vs. CG: 38 ng/dL, P < 0.001). Increases in uCysB and uClust suggest the presence of renal injury and a possible mechanism for the observed predisposition to chronic kidney disease in dogs with ehrlichiosis.-
Descrição: dc.descriptionDepartment of Clinical Sciences College of Veterinary Medicine North Carolina State University - NCSU-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University - UNESP-
Descrição: dc.descriptionIDEXX Laboratories Inc.-
Descrição: dc.descriptionAbbott Diagnostics Inc.-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University - UNESP-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleNovel renal injury markers in dogs with ehrlichiosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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