Fatal Myocarditis following COVID-19 mRNA Immunization: A Case Report and Differential Diagnosis Review

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Autor(es): dc.contributorUniversity Hospital of the Federal University of Maranhão-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSousa, Pedro Manuel Barros de-
Autor(es): dc.creatorSilva, Elon Almeida-
Autor(es): dc.creatorCampos, Marcos Adriano Garcia-
Autor(es): dc.creatorLages, Joyce Santos-
Autor(es): dc.creatorCorrêa, Rita da Graça Carvalhal Frazão-
Autor(es): dc.creatorSilva, Gyl Eanes Barros-
Data de aceite: dc.date.accessioned2025-08-21T18:39:17Z-
Data de disponibilização: dc.date.available2025-08-21T18:39:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/vaccines12020194-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301407-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301407-
Descrição: dc.descriptionCarditis in childhood is a rare disease with several etiologies. We report a case of infant death due to pericarditis and myocarditis after the mRNA vaccine against COVID-19 (COVIDmRNAV). A 7-year-old male child received the first dose of the COVIDmRNAV and presented with monoarthritis and a fever non-responsive to oral antibiotics. The laboratory investigation showed signs of infection (leukocytosis, high levels of c-reactive protein). His condition rapidly deteriorated, and the patient died. The autopsy identified pericardial fibrin deposits, hemorrhagic areas in the myocardium, and normal valves. A diffuse intermyocardial inflammatory infiltrate composed of T CD8+ lymphocytes and histiocytes was identified. An antistreptolysin O (ASO) dosage showed high titers. The presence of arthritis, elevated ASO, and carditis fulfills the criteria for rheumatic fever. However, valve disease and Aschoff’s nodules, present in 90% of rheumatic carditis cases, were absent in this case. The temporal correlation with mRNA vaccination prompted its inclusion as one of the etiologies. In cases of myocardial damage related to COVID-19mRNAV, it appears to be related to the expression of exosomes and lipid nanoparticles, leading to a cytokine storm. The potential effects of the COVID-19mRNAV must be considered in the pathogenesis of this disease, whether as an etiology or a contributing factor to a previously initiated myocardial injury.-
Descrição: dc.descriptionUniversity Hospital of the Federal University of Maranhão, Barão de Itapari Street 227, MA-
Descrição: dc.descriptionClinical Hospital of Botucatu Medical School São Paulo State University, Professor Mário Rubens Guimarães Montenegro Avenue, SP-
Descrição: dc.descriptionDepartment of Pathology Ribeirão Preto Medical School University of São Paulo, SP-
Descrição: dc.descriptionClinical Hospital of Botucatu Medical School São Paulo State University, Professor Mário Rubens Guimarães Montenegro Avenue, SP-
Idioma: dc.languageen-
Relação: dc.relationVaccines-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcathecolamin-induced cardiotoxicity-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectimmunization-
Palavras-chave: dc.subjectmRNA vaccine-
Palavras-chave: dc.subjectmultisystem inflammatory syndrome-
Palavras-chave: dc.subjectmyocarditis-
Palavras-chave: dc.subjectrheumatic heart disease-
Título: dc.titleFatal Myocarditis following COVID-19 mRNA Immunization: A Case Report and Differential Diagnosis Review-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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