A green approach for genistein and apigenin extraction optimization from by-products of soybean crops

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorThe University of Manchester-
Autor(es): dc.contributorUniversity of Aveiro (UA)-
Autor(es): dc.contributorUniversidad Politécnica de Madrid-
Autor(es): dc.creatorBragagnolo, Felipe Sanchez-
Autor(es): dc.creatorWojeicchowski, José Pedro-
Autor(es): dc.creatorSoukup-Carne, Dominik-
Autor(es): dc.creatorGonzález-Miquel, María-
Autor(es): dc.creatorEsteban, Jesús-
Autor(es): dc.creatorFunari, Cristiano Soleo-
Data de aceite: dc.date.accessioned2025-08-21T15:12:23Z-
Data de disponibilização: dc.date.available2025-08-21T15:12:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.scp.2023.101343-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301292-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301292-
Descrição: dc.descriptionSoybeans’ genistein and its isomer apigenin are widely studied bioactive compounds owing to their therapeutic potential for treating various health disfunctions. A green extraction of both from soy by-products could lead to a valuable and sustainable approach to adding value to these materials in a biorefinery context. Here Hansen Solubility Parameters (HSP) and the Conductor-like Screening MOdel for Real Solvents (COSMO-RS) were applied to screen green molecular solvents and Natural Eutectic Solvents for the extraction of genistein and apigenin from soy by-products. The predicted solubilities of genistein and apigenin in 18 shortlisted candidates were experimentally tested by dynamic maceration, the most industrially implemented natural products extraction technique. EtOH:H2O (8:2, v/v) and natural eutectic solvent (NAES) betaine:ethylene glycol (1:2, mol/mol) showed the highest performance. These were selected for extraction optimizations by Design of Experiments from soy branches, the largest by-product by mass. The optimum condition of each solvent was applied to extract all other parts of soy collected post-mechanical harvesting. The highest value of apigenin, 591.49 ± 26.7 μg/g, was achieved from soy pods with EtOH:H2O (8:2, v/v), while the highest of genistein, 54.04 ± 3.39 μg/g, was achieved from soybeans using the same solvent. Our findings highlight the necessity of exercising caution when interpreting in silico outcomes in the context of metabolite extractions from complex matrices. A trade-off between in silico solvent screening and experimental work should be followed when developing new phytochemical extraction processes. Furthermore, soy by-products emerged as competitive candidates for a long-term source of the bioactive apigenin in a biorefinery context.-
Descrição: dc.descriptionUniversity of Manchester-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionGreen Biotech Network School of Agricultural Sciences São Paulo State University (UNESP), Av. Universitária 3780, Botucatu-
Descrição: dc.descriptionDepartment of Chemical Engineering The University of Manchester, Oxford Road-
Descrição: dc.descriptionCICECO − Aveiro Institute of Materials Department of Chemistry University of Aveiro (UA)-
Descrição: dc.descriptionDepartment of Chemical and Environmental Engineering Higher Technical School of Industrial Engineering Universidad Politécnica de Madrid, José Gutiérrez Abascal 2-
Descrição: dc.descriptionGreen Biotech Network School of Agricultural Sciences São Paulo State University (UNESP), Av. Universitária 3780, Botucatu-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2014/50926-0-
Descrição: dc.descriptionFAPESP: 2017/06216-6-
Descrição: dc.descriptionFAPESP: 2018/01786-1-
Descrição: dc.descriptionFAPESP: 2018/21128-9-
Descrição: dc.descriptionFAPESP: 2022/00645-0-
Idioma: dc.languageen-
Relação: dc.relationSustainable Chemistry and Pharmacy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBioactive compounds-
Palavras-chave: dc.subjectBiorefinery-
Palavras-chave: dc.subjectComputational predictions-
Palavras-chave: dc.subjectGreen solvents-
Título: dc.titleA green approach for genistein and apigenin extraction optimization from by-products of soybean crops-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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