Are salivary NO2− / NO2− and NO3− levels biomarkers for dental caries in children? Systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAnn and Robert Lurie Childrens Hospital-
Autor(es): dc.contributorPostgraduate Program in Health Sciences-
Autor(es): dc.creatorDíaz-Fabregat, Beatriz-
Autor(es): dc.creatorRamírez-Carmona, Wilmer-
Autor(es): dc.creatorCannon, Mark Lloyd-
Autor(es): dc.creatorMonteiro, Douglas Roberto-
Autor(es): dc.creatorPessan, Juliano Pelim-
Autor(es): dc.creatorAntoniali, Cristina-
Data de aceite: dc.date.accessioned2025-08-21T21:19:05Z-
Data de disponibilização: dc.date.available2025-08-21T21:19:05Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.niox.2024.01.001-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301283-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301283-
Descrição: dc.descriptionThe literature is conflicting regarding salivary nitrite (NO2−)/nitrite and nitrate (NO2− and NO3−) levels in children affected by dental caries. For this reason, a systematic review to provide a consensus on the subject was propose, whose objective is to verify whether these molecules could be used as biomarkers in children with caries. A comprehensive search was performed on online database and eleven articles were included in the meta-analysis. The methodological quality of studies was assessed by Newcastle-Ottawa Scale recommended for case-control studies and by AXIS tool for cross-sectional studies. Grading of Recommendations Assessment, Development and Evaluation was used for the assessment of the certainty of the evidence for each outcome. The results showed lower NO2− levels in the group of children affected by dental caries (SMD = −2.18 [-3.24, −1.13], p < 0.01). Age, saliva collection and methods of evaluation can impact the results. When evaluating the severity of the condition, an important variation was detected in relation to the different evaluation methods NO2−/NO2− and NO3−. In conclusion, based on the evidence presented, the results suggest that NO2− levels in saliva are a possible biomarker of dental caries. Results should be evaluated with caution due to the very low evidence from primary studies. Longitudinal studies are necessary to strengthen this hypothesis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Araçatuba School of Dentistry Department of Preventive and Restorative Dentistry, Rua José Bonifácio 1193 Araçatuba, SP-
Descrição: dc.descriptionFeinberg School of Medicine Northwestern University Ann and Robert Lurie Childrens Hospital, 420 E Superior St-
Descrição: dc.descriptionUniversity of Western São Paulo (UNOESTE) Postgraduate Program in Health Sciences, Rua José Bongiovani 700 Presidente Prudente, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Araçatuba School of Dentistry Department of Basic Science, Rua José Bonifácio 1193 Araçatuba, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Araçatuba School of Dentistry Department of Preventive and Restorative Dentistry, Rua José Bonifácio 1193 Araçatuba, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Araçatuba School of Dentistry Department of Basic Science, Rua José Bonifácio 1193 Araçatuba, SP-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format11-19-
Idioma: dc.languageen-
Relação: dc.relationNitric Oxide - Biology and Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChild-
Palavras-chave: dc.subjectNitrates-
Palavras-chave: dc.subjectNitrites-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectPreschool-
Palavras-chave: dc.subjectSaliva-
Título: dc.titleAre salivary NO2− / NO2− and NO3− levels biomarkers for dental caries in children? Systematic review and meta-analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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