Spinal Involvement of TRPV1 and PI3K/AKT/mTOR Pathway During Chronic Postoperative Pain in Mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorPadre Gervásio National Institute of Higher Education and Postgraduate Studies-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSantos, Gabriela Xavier-
Autor(es): dc.creatordos Anjos-Garcia, Tayllon-
Autor(es): dc.creatorVieira, Ana Carolina de Jesus-
Autor(es): dc.creatorGaldino, Giovane-
Data de aceite: dc.date.accessioned2025-08-21T23:40:15Z-
Data de disponibilização: dc.date.available2025-08-21T23:40:15Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/brainsci15010053-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301233-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301233-
Descrição: dc.descriptionBackground: Chronic postoperative pain (CPOP) is among the main consequences of surgical procedures, directly affecting the quality of life. Although many strategies have been used to treat this symptom, they are often ineffective. Thus, studies investigating CPOP-associated mechanisms may help to develop more effective treatment strategies. Therefore, the present study investigated the spinal participation of the transient potential receptor vanilloid type 1 (TRPV1) and PI3K/AKT/mTOR pathway activation during CPOP. Methods: In this study C57BL/6 male mice were used, and CPOP was induced by muscle retraction and incision. The nociceptive threshold was measured by the von Frey filament test. For pharmacological evaluation, TRPV1 and PI3K/AKT/mTOR inhibitors were administered intrathecally. TRPV1 and PI3K/AKT/mTOR protein levels were evaluated by Western blotting. Results: The results showed that CPOP increased TRPV1 and mTOR protein levels, and pretreatment with the specific inhibitors alleviated CPOP. In addition, pretreatment with the TRPV1 antagonist SB-366791 attenuated mTOR protein levels. Conclusions: The results suggest that TRPV1 and the PI3K/AKT/mTOR pathway are involved in CPOP at the spinal level, and TRPV1 may activate mTOR during this process.-
Descrição: dc.descriptionCenter for Experimental Biology Laboratory of Neuroimmunobiology of Pain Federal University of Alfenas, MG-
Descrição: dc.descriptionInapós College Padre Gervásio National Institute of Higher Education and Postgraduate Studies, MG-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology of the Faculty of Agricultural and Veterinary Sciences of São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology of the Faculty of Agricultural and Veterinary Sciences of São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationBrain Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchronic postoperative pain-
Palavras-chave: dc.subjectmTOR-
Palavras-chave: dc.subjectPI3K-
Palavras-chave: dc.subjectTRPV1-
Título: dc.titleSpinal Involvement of TRPV1 and PI3K/AKT/mTOR Pathway During Chronic Postoperative Pain in Mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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