Description of blaKPC-carrying Escherichia coli in patients from a Brazilian hospital over a 4-year period

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFAMERP-
Autor(es): dc.contributorHospital de Base de São José do Rio Preto-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorThe University of Queensland-
Autor(es): dc.contributorLouisiana State University-
Autor(es): dc.creatorPradela, Letícia Kalir-
Autor(es): dc.creatorCasella, Tiago-
Autor(es): dc.creatorManieri, Fernanda Zani-
Autor(es): dc.creatorde Andrade, Letícia Kellen-
Autor(es): dc.creatorBarroso, Marlon do Valle-
Autor(es): dc.creatorNhu, Nguyen Thi Khanh-
Autor(es): dc.creatorSchembri, Mark Andrew-
Autor(es): dc.creatorMoreira, Cristiano Gallina-
Autor(es): dc.creatorNogueira, Mara Corrêa Lelles-
Data de aceite: dc.date.accessioned2025-08-21T18:04:14Z-
Data de disponibilização: dc.date.available2025-08-21T18:04:14Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.diagmicrobio.2025.116833-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301205-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301205-
Descrição: dc.descriptionKlebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli are recognized by the World Health Organization as a critical group of bacterial priority pathogens of public health importance. Thus, increased understanding of the genetic characteristics of KPC-producing E. coli is required. Here, we performed a retrospective study in a Brazilian teaching-hospital to describe the genomic features linked to antimicrobial resistance, virulence, and phylogeny of 40 meropenem-resistant E. coli. All isolates carried the blaKPC-2 gene, but amikacin, tigecycline, colistin, polymyxin B, and fosfomycin showed good activity. Molecular typing by MLST revealed 20 sequence types (STs), with a predominance of ST131. Whole-genome sequencing identified Tn4401 as a mechanism responsible for blaKPC-2 mobilization, a variety of antimicrobial resistance and virulence genes, the predominance of pathogenic phylogroup lineages, and the grouping of genomes belonging to the same ST. KPC-producing E. coli is not a common pathogen, but few treatment alternatives are available against potentially virulent strains.-
Descrição: dc.descriptionCentro de Investigação de Microrganismos FAMERP, 5416, Brigadeiro Faria Lima Avenue. Vila São Pedro, SP-
Descrição: dc.descriptionHospital de Base de São José do Rio Preto, 5544, Brigadeiro Faria Lima Avenue. Vila São Pedro, SP-
Descrição: dc.descriptionFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho”, Rodovia Araraquara-Jau, Km 01, SP-
Descrição: dc.descriptionInstitute for Molecular Bioscience (IMB) The University of Queensland-
Descrição: dc.descriptionAustralian Infectious Diseases Research Centre The University of Queensland-
Descrição: dc.descriptionSchool of Chemistry and Molecular Biosciences The University of Queensland-
Descrição: dc.descriptionDepartment of Biological Sciences Louisiana State University-
Descrição: dc.descriptionFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho”, Rodovia Araraquara-Jau, Km 01, SP-
Idioma: dc.languageen-
Relação: dc.relationDiagnostic Microbiology and Infectious Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCarbapenemase-
Palavras-chave: dc.subjectEpidemiology-
Palavras-chave: dc.subjectMultidrug-resistance-
Palavras-chave: dc.subjectUropathogenic Escherichia coli-
Palavras-chave: dc.subjectWhole-genome sequencing-
Título: dc.titleDescription of blaKPC-carrying Escherichia coli in patients from a Brazilian hospital over a 4-year period-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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