Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom

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Autor(es): dc.contributorUniversity of Brasília-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorThe University of Queensland-
Autor(es): dc.creatorGalante, Priscilla-
Autor(es): dc.creatorCampos, Gabriel A. A.-
Autor(es): dc.creatorMoser, Jacqueline C. G.-
Autor(es): dc.creatorMartins, Danubia B.-
Autor(es): dc.creatordos Santos Cabrera, Marcia P.-
Autor(es): dc.creatorRangel, Marisa-
Autor(es): dc.creatorCoelho, Luiza C.-
Autor(es): dc.creatorSimon, Karina S.-
Autor(es): dc.creatorAmado, Veronica M.-
Autor(es): dc.creatorde A. I. Muller, Jessica-
Autor(es): dc.creatorKoehbach, Johannes-
Autor(es): dc.creatorLohman, Rink-Jan-
Autor(es): dc.creatorCabot, Peter J.-
Autor(es): dc.creatorVetter, Irina-
Autor(es): dc.creatorCraik, David J.-
Autor(es): dc.creatorToffoli-Kadri, Monica C.-
Autor(es): dc.creatorMonge-Fuentes, Victoria-
Autor(es): dc.creatorGoulart, Jair T.-
Autor(es): dc.creatorSchwartz, Elisabeth F.-
Autor(es): dc.creatorSilva, Luciano P.-
Autor(es): dc.creatorBocca, Anamelia L.-
Autor(es): dc.creatorMortari, Márcia R.-
Data de aceite: dc.date.accessioned2025-08-21T17:46:22Z-
Data de disponibilização: dc.date.available2025-08-21T17:46:22Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-023-38828-w-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301186-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301186-
Descrição: dc.descriptionAnimal venoms are rich sources of neuroactive compounds, including anti-inflammatory, antiepileptic, and antinociceptive molecules. Our study identified a protonectin peptide from the wasp Parachartergus fraternus' venom using mass spectrometry and cDNA library construction. Using this peptide as a template, we designed a new peptide, protonectin-F, which exhibited higher antinociceptive activity and less motor impairment compared to protonectin. In drug interaction experiments with naloxone and AM251, Protonectin-F's activity was decreased by opioid and cannabinoid antagonism, two critical antinociception pathways. Further experiments revealed that this effect is most likely not induced by direct action on receptors but by activation of the descending pain control pathway. We noted that protonectin-F induced less tolerance in mice after repeated administration than morphine. Protonectin-F was also able to decrease TNF-α production in vitro and modulate the inflammatory response, which can further contribute to its antinociceptive activity. These findings suggest that protonectin-F may be a potential molecule for developing drugs to treat pain disorders with fewer adverse effects. Our results reinforce the biotechnological importance of animal venom for developing new molecules of clinical interest.-
Descrição: dc.descriptionFundação de Apoio à Pesquisa do Distrito Federal-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Neuropharmacology Department of Physiological Sciences University of Brasília, DF-
Descrição: dc.descriptionDepartment of Physics IBILCE São Paulo State University, SP-
Descrição: dc.descriptionImmunopathology Laboratory Butantan Institute, SP-
Descrição: dc.descriptionLaboratory of Nanobiotechnology Embrapa Genetic Resources and Biotechnology, DF-
Descrição: dc.descriptionLaboratory of Applied Immunology Department of Cell Biology University of Brasilia, DF-
Descrição: dc.descriptionFaculty of Medicine and University Hospital of Brasília University of Brasilia, DF-
Descrição: dc.descriptionLaboratory of Pharmacology and Inflammation FACFAN Federal University of Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionInstitute for Molecular Bioscience Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of Queensland-
Descrição: dc.descriptionSchool of Pharmacy The University of Queensland-
Descrição: dc.descriptionDepartment of Physics IBILCE São Paulo State University, SP-
Descrição: dc.descriptionFundação de Apoio à Pesquisa do Distrito Federal: 0001830016/2016-
Descrição: dc.descriptionCAPES: 001 Scholarship-
Descrição: dc.descriptionFundação de Apoio à Pesquisa do Distrito Federal: 193.000.882/2014-
Descrição: dc.descriptionCNPq: 407625/2013-5-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleExploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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