Clinical value of alpha-fetoprotein in the detection of mammary carcinoma in female dogs

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Vila Velha-
Autor(es): dc.creatorSenhorello, I. L. S.-
Autor(es): dc.creatorTerra, E. M.-
Autor(es): dc.creatorSueiro, F. A. R.-
Autor(es): dc.creatorPereira, R. S.-
Autor(es): dc.creatorFirmo, B. F.-
Autor(es): dc.creatorMartinelli, C.-
Autor(es): dc.creatorTinucci-Costa, M.-
Data de aceite: dc.date.accessioned2025-08-21T22:02:57Z-
Data de disponibilização: dc.date.available2025-08-21T22:02:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301173-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301173-
Descrição: dc.descriptionThis study aimed to assess the behavior of Alpha-Fetoprotein (AFP) in healthy female dogs, those with non-metastatic mammary carcinomas, and those with metastatic mammary carcinomas. Additionally, it aimed to evaluate serum levels concerning the clinical-pathological variables of diseased dogs. To achieve this, sera from 35 female dogs were utilized, divided into three groups: G1 (n=10), control group (dogs free of neoplasms); G2 (n=20), dogs with mammary carcinoma without lymph node metastasis; and G3 (n=5), dogs with mammary carcinoma with lymph node metastasis. AFP was measured through ELISA, and the results were assessed using the Tukey test with a significance level of 5% in terms of the marker's presence in the patient's serum, its relationship with the neoplasm's biological behavior, and the clinical-pathological alterations encountered. Additionally, sensitivity and specificity values were obtained to establish the clinical value of AFP as a serological marker. The results revealed that AFP values (p<0.001) were significantly higher in dogs with mammary carcinoma compared to healthy dogs. Furthermore, there was a significant increase in AFP in non-spayed animals (p=0.0307). The marker demonstrated a sensitivity of 92% and specificity of 90% in distinguishing diseased animals from healthy ones. No relationship was found between the variables of tumor size, lymph node metastasis, histological grade, necrosis, ulceration, and inflammation with AFP (p<0.05). The findings indicated that AFP is elevated in female dogs with mammary tumors and could be a promising marker for monitoring dogs with mammary neoplasms. Future studies that include patient follow-up will be necessary.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Med Vet, Aracatuba, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Vila Velha, UVV, Vila Velha, ES, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Med Vet, Aracatuba, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2015/15015-9-
Descrição: dc.descriptionFAPESP: 2016/00128-5-
Formato: dc.format10-
Idioma: dc.languageen-
Publicador: dc.publisherArquivo Brasileiro Medicina Veterinaria Zootecnia-
Relação: dc.relationArquivo Brasileiro De Medicina Veterinaria E Zootecnia-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectprognosis-
Palavras-chave: dc.subjectmammary tumor-
Palavras-chave: dc.subjectbiomarkers-
Palavras-chave: dc.subjectmetastasis-
Título: dc.titleClinical value of alpha-fetoprotein in the detection of mammary carcinoma in female dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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