Ozone therapy improves early stages of osseointegration in ovariectomized rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCollege of Dentistry-
Autor(es): dc.creatorda SILVA, William Phillip Pereira-
Autor(es): dc.creatorE Santos, João Matheus Fonseca-
Autor(es): dc.creatorde SOUZA, Mônica Caroline-
Autor(es): dc.creatorBarbosa, Stéfany-
Autor(es): dc.creatorSantos, Anderson Maikon de Souza-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorBassi, Ana Paula Farnezi-
Autor(es): dc.creatorSukotjo, Cortino-
Autor(es): dc.creatorFaverani, Leonardo Perez-
Data de aceite: dc.date.accessioned2025-08-21T22:14:31Z-
Data de disponibilização: dc.date.available2025-08-21T22:14:31Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2023-0172-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301138-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301138-
Descrição: dc.descriptionObjective: the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats. Methodology: ovariectomy was performed on 30 Wistar rats, aged six months (Rattus novergicus), and, after 90 days, osseointegrated implants were installed in each tibial metaphysis. The study groups were divided into the animals that received intraperitoneal ozone at a concentration of 700 mcg/kg — OZ Group (n=15) — and a control group that received an intraperitoneal saline solution and, for this reason, was named the SAL group (n=15). The applications for both groups occurred during the immediate post-operative period on the 2nd, 4th, 6th, 8th, 10th, and 12th day post-surgery. At various stages (14, 42, and 60 days), the animals were euthanized, and tests were performed on their tibiae. These tests include histomorphometric and immunohistochemical analyses, computerized microtomography, sampling in light-cured resin for calcified sections, and confocal microscopy. The obtained data were then analyzed using One-way ANOVA and the Shapiro-Wilk, Kruskal-Wallis, and student t-tests (P<0.05). Results: our findings indicate that the OZ group (3.26±0.20 mm) showed better cellular organization and bone neoformation at 14 days (SAL group, 0.90±1.42 mm) (P=0.001). Immunohistochemistry revealed that osteocalcin labeling was moderate in the OZ group and mild in the SAL group at 14 and 42 days post-surgery. The data from the analysis of calcified tissues (microtomography, histometric, and bone dynamism analysis) at 60 days showed no statistically significant differences between the groups (P=0.32). Conclusion: it was concluded that ozone therapy anticipated the initial phases of the peri-implant bone repair process.-
Descrição: dc.descriptionUniversidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Diagnóstico e Cirurgia-
Descrição: dc.descriptionUniversidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas-
Descrição: dc.descriptionUniversity of Illinois College of Dentistry Department of Restorative Dentistry-
Descrição: dc.descriptionUniversidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Diagnóstico e Cirurgia-
Descrição: dc.descriptionUniversidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Oral Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDental Implants-
Palavras-chave: dc.subjectDentistry-
Palavras-chave: dc.subjectOsteoporosis-
Palavras-chave: dc.subjectOzone-
Palavras-chave: dc.subjectPreclinical Drug Evaluation-
Título: dc.titleOzone therapy improves early stages of osseointegration in ovariectomized rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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