Core-Shell UCNP@MOF Nanoplatforms for Dual Stimuli-Responsive Doxorubicin Release

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.creatorAbuçafy, Marina P.-
Autor(es): dc.creatorRamin, Beatriz B. S.-
Autor(es): dc.creatorGraminha, Angelica E.-
Autor(es): dc.creatorSantos, Willy G.-
Autor(es): dc.creatorFrem, Regina C. G.-
Autor(es): dc.creatorNetto, Adelino V. G.-
Autor(es): dc.creatorPereira, José Clayston M.-
Autor(es): dc.creatorRibeiro, Sidney J. L.-
Data de aceite: dc.date.accessioned2025-08-21T21:10:06Z-
Data de disponibilização: dc.date.available2025-08-21T21:10:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsabm.4c01796-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301106-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301106-
Descrição: dc.descriptionNanocarrier systems with multifunctional capabilities hold great potential for targeted cancer therapy, particularly for breast cancer treatment. Metal-organic frameworks (MOFs) are notable for their high porosity and, in some cases, biocompatibility, with ZIF-8 being particularly advantageous due to its pH-sensitive degradability, enabling selective drug release in tumor environments. Additionally, lanthanide-doped upconversion nanoparticles (UCNPs) offer unique optical properties that enhance both imaging and therapeutic applications. In this study, NaYF4/Yb3+Er3+ UCNPs were synthesized via a hydrothermal method, subsequently coated with poly(acrylic acid) (PAA) and encapsulated within a ZIF-8 shell, forming of UCNP@ZIF-8 core-shell nanocomposites. This system was designed to leverage stimulation by a 980 nm laser and acidic pH to facilitate drug release. When exposed to this specific laser wavelength, the nanocomposites demonstrated significantly enhanced drug release, achieving up to 90% release of the incorporated antitumor drug, doxorubicin (DOX), in acidic environments. In vitro studies indicated selective cytotoxicity, with MCF-7 tumor cell viability decreasing from 85.7% to 20% following laser activation, while showing minimal toxicity toward healthy cells. These findings underscore the potential of the UCNP@ZIF-8 nanocarrier system as a pH and laser-responsive platform for improved cancer therapy, enabling precise control over drug delivery while minimizing side effects on surrounding healthy tissues.-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University, São Paulo-
Descrição: dc.descriptionFederal University of ABC UFABC, São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationACS Applied Bio Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectlaser stimulation-
Palavras-chave: dc.subjectmetal−organic frameworks-
Palavras-chave: dc.subjectmultifunctional nanocarrier systems-
Palavras-chave: dc.subjectpH-sensitive drug release-
Palavras-chave: dc.subjectupconversion nanoparticles-
Título: dc.titleCore-Shell UCNP@MOF Nanoplatforms for Dual Stimuli-Responsive Doxorubicin Release-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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