Antiviral Evaluation of New Synthetic Bioconjugates Based on GA-Hecate: A New Class of Antivirals Targeting Different Steps of Zika Virus Replication

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Glasgow-
Autor(es): dc.contributorThe Rockefeller University-
Autor(es): dc.contributorFederal University of Rondonópolis-
Autor(es): dc.creatorda Silva Sanches, Paulo Ricardo-
Autor(es): dc.creatorSanchez-Velazquez, Ricardo-
Autor(es): dc.creatorBatista, Mariana Nogueira-
Autor(es): dc.creatorCarneiro, Bruno Moreira-
Autor(es): dc.creatorBittar, Cintia-
Autor(es): dc.creatorDe Lorenzo, Giuditta-
Autor(es): dc.creatorRahal, Paula-
Autor(es): dc.creatorPatel, Arvind H.-
Autor(es): dc.creatorCilli, Eduardo Maffud-
Data de aceite: dc.date.accessioned2025-08-21T15:50:06Z-
Data de disponibilização: dc.date.available2025-08-21T15:50:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules28134884-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301067-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301067-
Descrição: dc.descriptionRe-emerging arboviruses represent a serious health problem due to their rapid vector-mediated spread, mainly in urban tropical areas. The 2013–2015 Zika virus (ZIKV) outbreak in South and Central America has been associated with cases of microcephaly in newborns and Guillain–Barret syndrome. We previously showed that the conjugate gallic acid—Hecate (GA-FALALKALKKALKKLKKALKKAL-CONH2)—is an efficient inhibitor of the hepatitis C virus. Here, we show that the Hecate peptide is degraded in human blood serum into three major metabolites. These metabolites conjugated with gallic acid were synthesized and their effect on ZIKV replication in cultured cells was evaluated. The GA-metabolite 5 (GA-FALALKALKKALKKL-COOH) was the most efficient in inhibiting two ZIKV strains of African and Asian lineage at the stage of both virus entry (virucidal and protective) and replication (post-entry). We also demonstrate that GA-metabolite 5 does not affect cell growth after 7 days of continuous treatment. Thus, this study identifies a new synthetic antiviral compound targeting different steps of ZIKV replication in vitro and with the potential for broad reactivity against other flaviviruses. Our work highlights a promising strategy for the development of new antivirals based on peptide metabolism and bioconjugation.-
Descrição: dc.descriptionMedical Research Council-
Descrição: dc.descriptionSchool of Pharmaceutical Science São Paulo State University, SP-
Descrição: dc.descriptionMRC—University of Glasgow Centre for Virus Research University of Glasgow-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University, SP-
Descrição: dc.descriptionLaboratory of Virology and Infectious Diseases The Rockefeller University-
Descrição: dc.descriptionSchool of Health Science Federal University of Rondonópolis, MT-
Descrição: dc.descriptionInstitute of Bioscience Humanities and Exact Science São Paulo State University, SP-
Descrição: dc.descriptionSchool of Pharmaceutical Science São Paulo State University, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University, SP-
Descrição: dc.descriptionInstitute of Bioscience Humanities and Exact Science São Paulo State University, SP-
Descrição: dc.descriptionMedical Research Council: MC_UU12014/2-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbioconjugates-
Palavras-chave: dc.subjectGA-Hecate-
Palavras-chave: dc.subjectGA-metabolites-
Palavras-chave: dc.subjectgallic acid-
Palavras-chave: dc.subjectHecate-
Palavras-chave: dc.subjectpeptides-
Palavras-chave: dc.subjectZika virus-
Título: dc.titleAntiviral Evaluation of New Synthetic Bioconjugates Based on GA-Hecate: A New Class of Antivirals Targeting Different Steps of Zika Virus Replication-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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