Does loss of CD44, low E-Cadherin and high Ki-67 expression in equine malignant melanoma have a relationship with biological behavior?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPathological Anatomy and Veterinary Clinical Pathology Ltda-
Autor(es): dc.contributorUniversidad Nacional de Colombia-
Autor(es): dc.creatorChaves Jorge, Alice-
Autor(es): dc.creatorDe Araújo Viana, Daniel-
Autor(es): dc.creatorRegina Zapaterini, Joyce-
Autor(es): dc.creatorMauricio Montoya-Flórez, Luis-
Autor(es): dc.creatorSousa Rocha, Noeme-
Data de aceite: dc.date.accessioned2025-08-21T17:11:36Z-
Data de disponibilização: dc.date.available2025-08-21T17:11:36Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.15381/rivep.v35i5.26141-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301063-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301063-
Descrição: dc.descriptionEquine melanoma affects all breeds and although 90% of melanocytic tumors in the species are benign, 66% of them progress to malignant forms and can metastasize, which translates into great economic losses for owners. For this, the investigation of prognostic factors and establishing their relationship with histopathological criteria is essential. The current work aimed to relate the expression of CD44, E-cadherin, and Ki67 with histopathological and cytological findings in equine melanomas, to identify a possible relationship between the anatomo-clinical expression and the biological behavior. Fifteen cases of melanoma in horses were selected, confirmed by cytopathological and/or histopathological exams (biopsy) taken from the files of the pathology laboratory of Universidade Estadual Paulista «Júlio de Mesquita Filho», Brazil. The samples were analyzed according to the presence of atypical cytological criteria and following the «Breslow» micrometric criteria. Subsequently, the samples were submitted to the immunohistochemical technique for S-100, CD44, Ki67, and E-cadherin (ECAD) markers. Descriptive statistics and non-parametric tests with significance p<0.05 were used for data analysis. In cytology, all samples showed a high degree of malignancy criteria, and all analyzed tumors were infiltrative (N3/TIII). CD44 expression was negative in all samples, the positivity rates for S-100, Ki67, and E-cadherin were 52.5, 50.43 and 10% respectively. It is suggested that the use of CD44, ECAD, and Ki67 together with cytopathological and histopathological analyses including the application of the «Breslow» criteria should be performed to identify equine melanomas with highest degree of aggressiveness and better establish the prognosis in this type of tumor.-
Descrição: dc.descriptionInvestigative and Comparative Pathology Laboratory School of Veterinary Medicine and Animal Science São Paulo State University (UNESP), Campus of Botucatu-
Descrição: dc.descriptionPathovet Laboratory Pathological Anatomy and Veterinary Clinical Pathology Ltda-
Descrição: dc.descriptionLaboratory of Chemical and Experimental Carcinogenesis Department of Morphology Institute of Biosciences São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionVeterinary Medicine Faculty Universidad Nacional de Colombia-
Descrição: dc.descriptionInvestigative and Comparative Pathology Laboratory School of Veterinary Medicine and Animal Science São Paulo State University (UNESP), Campus of Botucatu-
Descrição: dc.descriptionLaboratory of Chemical and Experimental Carcinogenesis Department of Morphology Institute of Biosciences São Paulo State University (UNESP), Botucatu-
Idioma: dc.languageen-
Relação: dc.relationRevista de Investigaciones Veterinarias del Peru-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBreslow-
Palavras-chave: dc.subjectimmunohistochemistry-
Palavras-chave: dc.subjectmelanoma-
Palavras-chave: dc.subjecttumor-
Título: dc.titleDoes loss of CD44, low E-Cadherin and high Ki-67 expression in equine malignant melanoma have a relationship with biological behavior?-
Título: dc.title¿la pérdida de CD44, baja expresión de E cadherina y alta expresión de Ki-67 en melanoma maligno equino tiene relación con su comportamiento biológico?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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