Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDe Lima Gualque, Marcos William-
Autor(es): dc.creatorVaso, Carolina Orlando-
Autor(es): dc.creatordos Santos, Kelvin Sousa-
Autor(es): dc.creatorGaleane, Mariana Cristina-
Autor(es): dc.creatorGomes, Paulo César-
Autor(es): dc.creatorPalma, Mario Sérgio-
Autor(es): dc.creatorSoares Mendes Giannini, Maria José-
Autor(es): dc.creatorMoroz, Andrei-
Autor(es): dc.creatorFusco Almeida, Ana Marisa-
Data de aceite: dc.date.accessioned2025-08-21T21:29:59Z-
Data de disponibilização: dc.date.available2025-08-21T21:29:59Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/17460913.2024.2421632-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301057-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301057-
Descrição: dc.descriptionAim: This work aimed to test peptides against the planktonic and biofilm form of Cryptococcus spp. and in vitro toxicity using three-dimensional (3D) cells characterized and evaluate in vivo toxicity in Galleria mellonella. Materials & methods: Susceptibility tests were conducted on the planktonic form and biofilm formation. The toxicity of the peptides was evaluated in lung and brain cells in monolayer (2D) and 3D mono- and co-culture, in addition to in vivo analysis with G. mellonella. Results: Susceptibility values ranged from 31.25 to over 250 µg/ml with a fungicidal profile. Regarding toxicity, the PepM2 peptide was not toxic in 3D culture (500 µg/ml). G. mellonella, showed a survival rate of more than 85% In assays with brain and lung cell lines, concentrations ranged from 4 × 104 to 4 × 103 cells/well for brain cells and 1 × 103 cells/well for lung cells. Cocultures used 1 × 105 brain and 1 × 103 lung cells. Conclusion: This study shows that the peptides have great potential against cryptococcosis, and all spheroids were characterized as having a spheroidal and compact structure.-
Descrição: dc.descriptionLaboratory of Mycology & Center of Proteomics Department of Clinical Analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory for Monoclonal Antibodies Department of Clinical Analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Basic & Applied Biology/LSBZ Institute of Biosciences São Paulo State University-UNESP, São Paulo-
Descrição: dc.descriptionLaboratory of Mycology & Center of Proteomics Department of Clinical Analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory for Monoclonal Antibodies Department of Clinical Analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Basic & Applied Biology/LSBZ Institute of Biosciences São Paulo State University-UNESP, São Paulo-
Formato: dc.format11-21-
Idioma: dc.languageen-
Relação: dc.relationFuture Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal-
Palavras-chave: dc.subjectbiofilm-
Palavras-chave: dc.subjectcryptococcosis-
Palavras-chave: dc.subjectGalleria mellonella-
Palavras-chave: dc.subjectlung coculture-
Palavras-chave: dc.subjectthree-dimensional culture-
Título: dc.titlePeptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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