Influence of Zinc on Histoplasma capsulatum Planktonic and Biofilm Cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorPires, Ana Carolina Moreira da Silva-
Autor(es): dc.creatorCarvalho, Angélica Romão-
Autor(es): dc.creatorVaso, Carolina Orlando-
Autor(es): dc.creatorMendes-Giannini, Maria José Soares-
Autor(es): dc.creatorSingulani, Junya de Lacorte-
Autor(es): dc.creatorFusco-Almeida, Ana Marisa-
Data de aceite: dc.date.accessioned2025-08-21T21:48:34Z-
Data de disponibilização: dc.date.available2025-08-21T21:48:34Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof10050361-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301034-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301034-
Descrição: dc.descriptionHistoplasma capsulatum causes a fungal respiratory disease. Some studies suggest that the fungus requires zinc to consolidate the infection. This study aimed to investigate the influence of zinc and the metal chelator TPEN on the growth of Histoplasma in planktonic and biofilm forms. The results showed that zinc increased the metabolic activity, cell density, and cell viability of planktonic growth. Similarly, there was an increase in biofilm metabolic activity but no increase in biomass or extracellular matrix production. N′-N,N,N,N–tetrakis–2-pyridylmethylethane–1,2 diamine (TPEN) dramatically reduced the same parameters in the planktonic form and resulted in a decrease in metabolic activity, biomass, and extracellular matrix production for the biofilm form. Therefore, the unprecedented observations in this study highlight the importance of zinc ions for the growth, development, and proliferation of H. capsulatum cells and provide new insights into the role of metal ions for biofilm formation in the dimorphic fungus Histoplasma, which could be a potential therapeutic strategy.-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biological Sciences Universidade Federal de Minas Gerais, MG-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiofilm-
Palavras-chave: dc.subjectHistoplasma capsulatum-
Palavras-chave: dc.subjecthistoplasmosis-
Palavras-chave: dc.subjectmetallic ions-
Palavras-chave: dc.subjectTPEN-
Palavras-chave: dc.subjectzinc-
Título: dc.titleInfluence of Zinc on Histoplasma capsulatum Planktonic and Biofilm Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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