Coamorphous Systems of Valsartan: Thermal Analysis Contribution to Evaluate Intermolecular Interactions Effects on the Structural Relaxation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Coimbra-
Autor(es): dc.contributorUniversidade de Lisboa-
Autor(es): dc.creatorEkawa, Bruno-
Autor(es): dc.creatorDiogo, Hermínio P.-
Autor(es): dc.creatorCastro, Ricardo A. E.-
Autor(es): dc.creatorCaires, Flávio J.-
Autor(es): dc.creatorEusébio, M. Ermelinda S.-
Data de aceite: dc.date.accessioned2025-08-21T19:06:23Z-
Data de disponibilização: dc.date.available2025-08-21T19:06:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules28176240-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301032-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301032-
Descrição: dc.descriptionCoamorphous formation in binary systems of valsartan (Val) with 4,4′-bipyridine (Bipy) and trimethoprim (Tri) was investigated for mixtures with a mole fraction of 0.16~0.86 of valsartan and evaluated in terms of the glass transition temperature. The glass transition of the systems had a behavior outside the values predicted by the Gordon–Taylor equation, showing that Val-Bipy (hydrogen bonding between the components) had a lower deviation and Val-Tri (ionic bonding between the components) had a higher deviation. Mixtures of compositions 2:1 Val-Bipy and 1:1 Val-Tri were selected for further investigation and verified to be stable, as no crystallization was observed during subsequent heating and cooling programs. For these systems, the effective activation energy during glass transition was evaluated. Compared to pure valsartan, the system with the lower glass transition temperature (Val-Bipy) presented the highest effective activation energy, and the system with the higher glass transition temperature (Val-Tri) presented a lower effective activation energy. The results presented a good correlation between the data obtained from two different techniques to determine the fragility and effective activation energy: non-isothermal kinetic analysis by DSC and TSDC.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionCoimbra Chemistry Center Institute of Molecular Sciences Department of Chemistry University of Coimbra-
Descrição: dc.descriptionCentro de Química Estrutural Institute of Molecular Sciences Departamento de Engenharia Química Instituto Superior Técnico Universidade de Lisboa-
Descrição: dc.descriptionSchool of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2018/24378-6-
Descrição: dc.descriptionCNPq: 317282/2021-2-
Descrição: dc.descriptionCNPq: 422893/2021-8-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcoamorphous-
Palavras-chave: dc.subjectglass transition-
Palavras-chave: dc.subjectisoconversional kinetics-
Palavras-chave: dc.subjectTSDC-
Palavras-chave: dc.subjectvalsartan-
Título: dc.titleCoamorphous Systems of Valsartan: Thermal Analysis Contribution to Evaluate Intermolecular Interactions Effects on the Structural Relaxation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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