Novel nimesulide multicomponent solid forms: screening, synthesis, thermoanalytical study and characterization

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Coimbra-
Autor(es): dc.creatorde Almeida, Amanda Cosmo-
Autor(es): dc.creatorFerreira, Patrícia Osório-
Autor(es): dc.creatorPorto, Maria Vitória-
Autor(es): dc.creatorCanotilho, João-
Autor(es): dc.creatorde Castro, Ricardo António Esteves-
Autor(es): dc.creatorCaires, Flávio Junior-
Autor(es): dc.creatorda Silva Eusébio, Maria Ermelinda-
Data de aceite: dc.date.accessioned2025-08-21T21:03:29Z-
Data de disponibilização: dc.date.available2025-08-21T21:03:29Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10973-024-13189-2-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301028-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301028-
Descrição: dc.descriptionNimesulide (NMS) is a widely used non-steroidal anti-inflammatory drug, however, presents low aqueous solubility. One way to overcome the solubility issue of drugs is altering their solid forms through some approaches like cocrystals, coamorphous, and eutectic mixtures. The purpose of this work was to prospect new multicomponent solid forms of NMS. A virtual-experimental cocrystal screening was carried out through COSMOquick software and mechanochemical experiments. Alternatively, dual-drug coamorphous systems were investigated by quench cooling and/or cryomilling processes. All solid samples were characterized using differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and infrared spectroscopy (FTIR). The results confirmed the successful synthesis of a NMS-piperazine cocrystal (NMS-PPZ), two new eutectic mixtures NMS-gentisic acid (NMS-GSA) and NMS-isoniazid (NMS-INH), as well as novel drug-drug coamorphous systems. The eutectic compositions were determined by binary solid–liquid phase diagram construction and Tamman’s triangle plot. Nimesulide-omeprazole (NMS-OMP) coamorphous system was found to be stable for at least 120 days in dry conditions. The coamorphous system with bicalutamide (NMS-BICA) prepared by quench cooling process is more stable than that obtained by cryomilling. Finally, the dissolution rate study demonstrated that NMS multicomponent systems are dissolved relatively faster than pure drug.-
Descrição: dc.descriptionSchool of Sciences São Paulo State University (Unesp)-
Descrição: dc.descriptionChemistry Department CQC/IMS University of Coimbra-
Descrição: dc.descriptionFaculty of Pharmacy University of Coimbra-
Descrição: dc.descriptionSchool of Sciences São Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Thermal Analysis and Calorimetry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDissolution rate study-
Palavras-chave: dc.subjectDual-drug solid systems-
Palavras-chave: dc.subjectNon-steroidal anti-inflammatory drug-
Palavras-chave: dc.subjectThermal analysis-
Palavras-chave: dc.subjectVirtual-experimental screening-
Título: dc.titleNovel nimesulide multicomponent solid forms: screening, synthesis, thermoanalytical study and characterization-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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