Protective role of calcium-based agents in dental bleaching gels: insights from a systematic review and meta-analysis of clinical and laboratory evidence

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Porto-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorNunes, Gabriel Pereira-
Autor(es): dc.creatorde Oliveira Alves, Renata-
Autor(es): dc.creatorPeres, Geórgia Rondó-
Autor(es): dc.creatorRagghianti, Matheus Henrique Faccioli-
Autor(es): dc.creatorde Toledo, Priscila Toninatto Alves-
Autor(es): dc.creatordos Reis Prado, Alexandre Henrique-
Autor(es): dc.creatorFerreira-Baptista, Carla-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Data de aceite: dc.date.accessioned2025-08-21T18:50:30Z-
Data de disponibilização: dc.date.available2025-08-21T18:50:30Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-025-06265-w-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301012-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301012-
Descrição: dc.descriptionObjectives: This systematic review and meta-analysis (SRM) evaluated the effect of incorporating calcium-based bioactive agents in bleaching gels on dental structure preservation and whitening efficacy. Methods: A comprehensive search was conducted across databases up to November 2024. Two independent reviewers screened and selected clinical trials and in vitro studies evaluating the effects of calcium-based bioactive agents in bleaching gels, following predefined PICO criteria. Data extraction and quality assessments were performed using the Cochrane Collaboration tool and Joanna Briggs Institute Critical Appraisal Tools. Meta-analyses were conducted with RevMan software, using the mean difference as the effect measure. Results: Out of 4,289 articles identified, 56 met the inclusion criteria, consisting of 50 in vitro studies and 6 clinical trials. The agents evaluated included calcium ions, calcium gluconate, amorphous calcium phosphate, CPP-ACP, and calcium polyphosphate. Overall, all agents reduced the adverse effects associated with bleaching therapy, such as minimizing changes in the mechanical and morphological properties of enamel, reducing transamelodentinal diffusion, and clinically decreasing tooth sensitivity. None of the calcium-based agents interfered with the bleaching effect. In short, the studies demonstrated a low risk of bias. Conclusions: Calcium-based agents incorporated into bleaching gels reduced bleaching-induced changes in dental tissues and demonstrated clinical aesthetic results comparable to conventional gels. However, further clinical trials are needed to optimize formulations, application protocols, and confirm the findings of this study. Clinical relevance. This SRM provides evidence that these agents offer additional benefits by enhancing the biocompatibility and safety of whitening therapy over conventional treatments, guiding clinicians in material selection for whitening procedures.-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry Araçatuba School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionLaboratory for Bone Metabolism and Regeneration (Bonelab) Faculty of Dental Medicine University of Porto-
Descrição: dc.descriptionDepartment of Operative Dentistry Endodontics and Dental Materials Bauru School of Dentistryaq São Paulo University (USP), Sao Paulo-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry Araçatuba School of Dentistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCalcium-
Palavras-chave: dc.subjectCarbamide peroxide-
Palavras-chave: dc.subjectDentin desensitizing agents-
Palavras-chave: dc.subjectHydrogen peroxide-
Palavras-chave: dc.subjectTooth bleaching-
Título: dc.titleProtective role of calcium-based agents in dental bleaching gels: insights from a systematic review and meta-analysis of clinical and laboratory evidence-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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