Cubosomes functionalized with antibodies as a potential strategy for the treatment of HER2-positive breast cancer

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorETH Zurich-
Autor(es): dc.contributorPaul Scherrer Institute (PSI)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorQingdao Agricultural University-
Autor(es): dc.creatorVictorelli, Francesca Damiani-
Autor(es): dc.creatorLutz-Bueno, Viviane-
Autor(es): dc.creatorSantos, Kaio Pini-
Autor(es): dc.creatorWu, Di-
Autor(es): dc.creatorSturla, Shana J.-
Autor(es): dc.creatorMezzenga, Raffaele-
Data de aceite: dc.date.accessioned2025-08-21T22:59:12Z-
Data de disponibilização: dc.date.available2025-08-21T22:59:12Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jcis.2024.06.091-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301007-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301007-
Descrição: dc.descriptionBreast cancers that overexpress human epidermal growth factor receptor 2 (HER2) have poor prognosis. Moreover, available chemotherapies cause numerous side effects due to poor selectivity. To advance more effective and safer therapies for HER2-positive breast cancer, we explored the fusion of drug delivery technology and immunotherapy. Our research led to the design of immunocubosomes loaded with panobinostat and functionalized with trastuzumab antibodies, enabling precise targeting of breast cancer cells that overexpress HER2. We characterised the nanostructure of cubosomes using small-angle X-ray scattering (SAXS), cryo-transmission electron microscopy (cryo-TEM), and dynamic light scattering (DLS). Moreover, we confirmed the integrity of the trastuzumab antibodies on the immunocubosomes by Fourier-transform infrared spectroscopy (FTIR) and sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Additionally, we found that panobinostat-loaded immunocubosomes were more cytotoxic, and in an uptake-dependant manner, towards a HER2-positive breast cancer cell line (SKBR3) compared to a cell line representing healthy cells (L929). These results support that the functionalization of cubosomes with antibodies enhances both the effectiveness of the loaded drug and its selectivity for targeting HER2-positive breast cancer cells.-
Descrição: dc.descriptionDepartment of Health Sciences and Technology ETH Zurich-
Descrição: dc.descriptionPaul Scherrer Institute (PSI)-
Descrição: dc.descriptionDepartment of Drugs and Medicine School of Pharmaceutical Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionCollege of Food Science and Engineering Qingdao Agricultural University, Shandong-
Descrição: dc.descriptionDepartment of Materials ETH Zurich-
Descrição: dc.descriptionDepartment of Drugs and Medicine School of Pharmaceutical Sciences São Paulo State University, São Paulo-
Formato: dc.format291-300-
Idioma: dc.languageen-
Relação: dc.relationJournal of Colloid and Interface Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBreast cancer-
Palavras-chave: dc.subjectCubosomes-
Palavras-chave: dc.subjectDrug delivery-
Palavras-chave: dc.subjectMonoclonal antibody-
Palavras-chave: dc.subjectPanobinostat-
Palavras-chave: dc.subjectTargeting-
Título: dc.titleCubosomes functionalized with antibodies as a potential strategy for the treatment of HER2-positive breast cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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