Hybrid Nanoparticles Dual-Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Groningen-
Autor(es): dc.contributorUniversidade de Lisboa-
Autor(es): dc.contributorUniversity of Turku-
Autor(es): dc.contributorUniversity of Helsinki-
Autor(es): dc.creatorCarvalho, Gabriela C.-
Autor(es): dc.creatorDomingues, Maria Nolasco Viseu-
Autor(es): dc.creatorMarena, Gabriel Davi-
Autor(es): dc.creatorMäkilä, Ermei-
Autor(es): dc.creatorLi, Jiachen-
Autor(es): dc.creatorGeertsema-Doornbusch, Gésinda-
Autor(es): dc.creatorde Andrade, Cleverton Roberto-
Autor(es): dc.creatorStuart, Marc C. A.-
Autor(es): dc.creatorShahbazi, Mohammad-Ali-
Autor(es): dc.creatorCorrêa, Ione-
Autor(es): dc.creatorPeterson, Brandon W.-
Autor(es): dc.creatorSalonen, Jarno-
Autor(es): dc.creatorFlorindo, Helena F.-
Autor(es): dc.creatorBauab, Taís Maria-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorSantos, Hélder A.-
Data de aceite: dc.date.accessioned2025-08-21T23:36:16Z-
Data de disponibilização: dc.date.available2025-08-21T23:36:16Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/adtp.202400342-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300967-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300967-
Descrição: dc.descriptionVulvovaginal candidiasis represents a public health challenge due to its reports of high incidence and recurrence. These are caused by host-related factors like compromised immune system, or pathogen-related factors, such as resistance to antifungal agents, making this medical problem desirable to develop new therapeutic options. In this context, natural origin substances like curcumin, are increasingly treatment alternatives. However, some curcumin properties limit its therapeutic application, such as insolubility in aqueous solvents, which leads to low bioavailability. Nevertheless, nanotechnology association with drugs of plant origin proves to be a promising alternative to overcome the reported drawbacks. Despite being caused by a fungus, patients suffer significantly from the inflammation resulting from this disease, thus this study aimed to develop a hybrid carrier nanoformulation by microfluidics loaded with two drugs, benzydamine hydrochloride (an anti-inflammatory drug) and curcumin (an antifungal drug). Transmission electron cryomicroscopy combined with energy dispersive X-ray analysis confirmed that the nanoparticle is properly developed. Through in vitro biological studies, it is possible to observe that, in addition to being safe, the encapsulation of both drugs in the nanocarrier drastically reduced their cytotoxicity. Finally, although the final nanoformulation does not show in vitro activity, the in vivo study indicated therapeutic potential.-
Descrição: dc.descriptionUniversitair Medisch Centrum Groningen-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville-
Descrição: dc.descriptionDepartment of Biomaterials and Biomedical Technology The Personalized Medicine Research Institute (PRECISION) University Medical Center Groningen University of Groningen, Ant. Deusinglaan 1, AV-
Descrição: dc.descriptionResearch Institute for Medicines (iMed.ULisboa) Faculdade de Farmácia Universidade de Lisboa, Av. Prof. Gama Pinto-
Descrição: dc.descriptionLaboratory of Industrial Physics Department of Physics and Astronomy University of Turku, Vesilinnantie 5-
Descrição: dc.descriptionAraraquara Dental School São Paulo State University (UNESP), Humaitá, 1680-
Descrição: dc.descriptionGroningen Biomolecular Sciences and Biotechnology Institute University of Groningen, Nijenborgh 7-
Descrição: dc.descriptionMedical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n-
Descrição: dc.descriptionDrug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki, Viikinkaari 5-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville-
Descrição: dc.descriptionAraraquara Dental School São Paulo State University (UNESP), Humaitá, 1680-
Descrição: dc.descriptionMedical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n-
Descrição: dc.descriptionFAPESP: 22/02187-0;19/26821-7;19/09831-9-
Idioma: dc.languageen-
Relação: dc.relationAdvanced Therapeutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbenzydamine hydrochloride-
Palavras-chave: dc.subjectcurcumin-
Palavras-chave: dc.subjectlipids-
Palavras-chave: dc.subjectmesoporous silica nanoparticles-
Palavras-chave: dc.subjectthermo-responsive hydrogel-
Palavras-chave: dc.subjectvulvovaginal candidiasis-
Título: dc.titleHybrid Nanoparticles Dual-Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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