Combined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorPinto, Ana P.-
Autor(es): dc.creatorSarni, Ângelo Augusto J.-
Autor(es): dc.creatorTavares, Maria Eduarda A.-
Autor(es): dc.creatorda Rocha, Alisson L.-
Autor(es): dc.creatorCarolino, Ruither O. Gomes-
Autor(es): dc.creatorde Sousa Neto, Ivo V.-
Autor(es): dc.creatorDa Silva Ferreira, Driele C.-
Autor(es): dc.creatorMunoz, Vitor R.-
Autor(es): dc.creatorTeixeira, Giovana R.-
Autor(es): dc.creatorSimabuco, Fernando M.-
Autor(es): dc.creatorPauli, José R.-
Autor(es): dc.creatorCintra, Dennys E.-
Autor(es): dc.creatorRopelle, Eduardo R.-
Autor(es): dc.creatorde Freitas, Ellen C.-
Autor(es): dc.creatorda Silva, Adelino S. R.-
Data de aceite: dc.date.accessioned2025-08-21T16:46:12Z-
Data de disponibilização: dc.date.available2025-08-21T16:46:12Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00424-024-03048-2-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300958-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300958-
Descrição: dc.descriptionThe Notch signaling pathway is crucial for skeletal muscle development, regeneration, inflammation, and aging. This study investigated the association between interleukin-10 (IL-10) and the Notch pathway in C2C12 cells, as well as explored the effects of combined endurance and resistance exercise on the Notch and autophagy pathways in the skeletal muscle of senescence-accelerated mouse-resistant 1 Sedentary (SAMR1 CT), SAMR1 exercised (SAMR1 EX), senescence-accelerated prone mouse 8 Sedentary (SAMP8 CT), and SAMP8 exercised (SAMP8 EX). C2C12 myoblasts were transfected with siIL-10. Histological analysis, reverse transcription-quantitative polymerase chain reaction, and immunoblotting were performed on the quadriceps and tibialis anterior muscles. A publicly available dataset was analyzed to assess the Notch pathway in older men. In summary, IL-10 knockdown in myoblasts reduced the Notch pathway gene and protein expression. In SAMP8 mice, combined exercise improved muscle fiber organization, enhanced balance and coordination, and increased Notch2 and Hes1 mRNA levels. NOTCH2 mRNA levels were also higher in older men compared to young subjects with similar physical activity levels. These findings suggest that combined physical exercise enhances muscle regeneration via the Notch pathway in aged muscle.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP), Avenida Bandeirantes, 3900, Monte Alegre, São Paulo-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP), São Paulo-
Descrição: dc.descriptionMulticentric Program of Postgraduate in Physiological Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise (LaBMEx) School of Applied Sciences University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionDepartment of Biochemistry Federal University of São Paulo (UNIFESP)-
Descrição: dc.descriptionDepartment of Health Sciences Ribeirão Preto Medical School University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP), São Paulo-
Descrição: dc.descriptionMulticentric Program of Postgraduate in Physiological Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2019/11820–5-
Descrição: dc.descriptionFAPESP: 2021/08693–1-
Descrição: dc.descriptionFAPESP: 2022/01957–6-
Descrição: dc.descriptionFAPESP: 2022/06807-2-
Descrição: dc.descriptionCNPq: 303766/2022-0-
Descrição: dc.descriptionCNPq: 308999/2022-3-
Formato: dc.format393-405-
Idioma: dc.languageen-
Relação: dc.relationPflugers Archiv European Journal of Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectMolecular pathway-
Palavras-chave: dc.subjectMuscle development-
Palavras-chave: dc.subjectPhysical exercise-
Título: dc.titleCombined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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