Coconut oil affects aging-related changes in Mongolian gerbil liver morphophysiology

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Viçosa-
Autor(es): dc.creatorGrigio, Vitor-
Autor(es): dc.creatorGuerra, Luiz Henrique Alves-
Autor(es): dc.creatorSilva, Stella Bicalho-
Autor(es): dc.creatorFreitas, Mariella Bontempo-
Autor(es): dc.creatorTaboga, Sebastião Roberto-
Autor(es): dc.creatorVilamaior, Patrícia Simone Leite-
Data de aceite: dc.date.accessioned2025-08-21T23:17:03Z-
Data de disponibilização: dc.date.available2025-08-21T23:17:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jnutbio.2024.109749-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300865-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300865-
Descrição: dc.descriptionAging causes changes in liver morphophysiology, altering hepatocyte morphology and organ function. Due to its antioxidant and anti-inflammatory properties, coconut oil has been used as a therapeutic agent in diets, in an attempt to attenuate alterations in the liver naturally caused by aging. Herein, we evaluated the effects of coconut oil consumption during aging on Mongolian gerbil liver morphophysiology. The animals were divided into three experimental groups: the gerbils in the Adult Control Group (AC) were euthanized at 3 months of age, the gerbils in the Old Control Group (OC) at 15 months of age, and the gerbils in the Coconut Oil Group (CO) received 0.1 ml/day of coconut oil for 12 months and were euthanized at 15 months of age. Prolonged consumption of coconut oil during aging prevented the animals and the liver from gaining mass. However, the other results showed that coconut oil intensified the morphophysiological alterations of aging, promoting an increase in the hepatocyte cytoplasm and nuclei. In addition, an increase in blood vessels, reticular fibers, lipid droplets, and lipofuscin granules were observed in the CO group. Finally, the results also demonstrated that coconut oil promotes an increase in lipid peroxidation, indicated by an increase in MDA levels. We therefore conclude that coconut oil has the potential to intensify the morphophysiological alterations that occur in the liver during aging.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Animal Biology Federal University of Viçosa, Minas Gerais-
Descrição: dc.descriptionDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 121054/2020-9 (VG)-
Descrição: dc.descriptionCNPq: 140841/2021-0 (SBS)-
Descrição: dc.descriptionCNPq: 312111/2023-1-
Descrição: dc.descriptionCNPq: 432360/2018-2-
Idioma: dc.languageen-
Relação: dc.relationJournal of Nutritional Biochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiogenesis-
Palavras-chave: dc.subjectAntioxidants-
Palavras-chave: dc.subjectLipid peroxidation-
Palavras-chave: dc.subjectNatural compounds-
Palavras-chave: dc.subjectPhytotherapy-
Título: dc.titleCoconut oil affects aging-related changes in Mongolian gerbil liver morphophysiology-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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