Study of IsCT analogue peptide against Candida albicans and toxicity/teratogenicity in zebrafish embryos (Danio rerio)

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGaleane, Mariana C.-
Autor(es): dc.creatorGomes, Paulo C.-
Autor(es): dc.creatorSingulani, Junya L.-
Autor(es): dc.creatorMendes-Giannini, Maria J.S.-
Autor(es): dc.creatorFusco-Almeida, Ana M.-
Data de aceite: dc.date.accessioned2025-08-21T19:21:40Z-
Data de disponibilização: dc.date.available2025-08-21T19:21:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/fmb-2022-0210-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300831-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300831-
Descrição: dc.descriptionAim: An IsCT analogue peptide (PepM3) was designed based on structural studies of wasp mastoparans and tested against Candida albicans. Its effects on fungal cell membranes and toxicity were evaluated. Materials & methods: Antifungal activity was analyzed using a microdilution susceptibility test. Toxicity was assessed using human skin keratinocytes (HaCaT) and zebrafish embryos. Results: PepM3 demonstrated activity against C. albicans and a synergistic effect with amphotericin B. The peptide presented fungicidal action with damage to the fungal cell membrane, low toxicity in HaCat cells and was nonteratogenic in zebrafish embryos. Conclusion: Evaluating structural modifications is essential for the development of new agents with potential activity against fungal pathogens and for the reduction of toxic and teratogenic effects.-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-UNESP-
Formato: dc.format939-947-
Idioma: dc.languageen-
Relação: dc.relationFuture Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal peptide-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectmass spectrometry-
Palavras-chave: dc.subjecttoxicity-
Palavras-chave: dc.subjectzebrafish-
Título: dc.titleStudy of IsCT analogue peptide against Candida albicans and toxicity/teratogenicity in zebrafish embryos (Danio rerio)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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