Copaifera langsdorffii Oleoresin-Loaded Nanostructured Lipid Carrier Emulgel Improves Cutaneous Healing by Anti-Inflammatory and Re-Epithelialization Mechanisms

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGushiken, Lucas F. S.-
Autor(es): dc.creatorBeserra, Fernando P.-
Autor(es): dc.creatorHussni, Maria F.-
Autor(es): dc.creatorGonzaga, Murilo T.-
Autor(es): dc.creatorRibeiro, Victor P.-
Autor(es): dc.creatorde Souza, Patrícia F.-
Autor(es): dc.creatorCampos, Jacqueline C. L.-
Autor(es): dc.creatorMassaro, Tais N. C.-
Autor(es): dc.creatorHussni, Carlos A.-
Autor(es): dc.creatorTakahira, Regina K.-
Autor(es): dc.creatorMarcato, Priscyla D.-
Autor(es): dc.creatorBastos, Jairo K.-
Autor(es): dc.creatorPellizzon, Cláudia H.-
Data de aceite: dc.date.accessioned2025-08-21T20:33:51Z-
Data de disponibilização: dc.date.available2025-08-21T20:33:51Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms242115882-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300828-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300828-
Descrição: dc.descriptionThe skin is essential to the integrity of the organism. The disruption of this organ promotes a wound, and the organism starts the healing to reconstruct the skin. Copaifera langsdorffii is a tree used in folk medicine to treat skin affections, with antioxidant and anti-inflammatory properties. In our study, the oleoresin of the plant was associated with nanostructured lipid carriers, aiming to evaluate the healing potential of this formulation and compare the treatment with reference drugs used in wound healing. Male Wistar rats were used to perform the excision wound model, with the macroscopic analysis of wound retraction. Skin samples were used in histological, immunohistochemical, and biochemical analyses. The results showed the wound retraction in the oleoresin-treated group, mediated by α-smooth muscle actin (α-SMA). Biochemical assays revealed the anti-inflammatory mechanism of the oleoresin-treated group, increasing interleukin-10 (IL-10) concentration and decreasing pro-inflammatory cytokines. Histopathological and immunohistochemical results showed the improvement of re-epithelialization and tissue remodeling in the Copaifera langsdorffii group, with an increase in laminin-γ2, a decrease in desmoglein-3 and an increase in collagen remodeling. These findings indicate the wound healing potential of nanostructured lipid carriers associated with Copaifera langsdorffii oleoresin in skin wounds, which can be helpful as a future alternative treatment for skin wounds.-
Descrição: dc.descriptionHematology and Transfusion Center University of Campinas—UNICAMP, SP-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo—USP, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Zootechnics São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Zootechnics São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Zootechnics São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Zootechnics São Paulo State University—UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanti-inflammatory-
Palavras-chave: dc.subjectCopaifera langsdorffii-
Palavras-chave: dc.subjectemulgel-
Palavras-chave: dc.subjectnanostructured lipid carrier-
Palavras-chave: dc.subjectre-epithelialization-
Palavras-chave: dc.subjectskin-
Palavras-chave: dc.subjectwound healing-
Título: dc.titleCopaifera langsdorffii Oleoresin-Loaded Nanostructured Lipid Carrier Emulgel Improves Cutaneous Healing by Anti-Inflammatory and Re-Epithelialization Mechanisms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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