Childhood-onset systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.creatorBrufatto, Matheus Zanata-
Autor(es): dc.creatorLanças, Sean Hideo Shirata-
Autor(es): dc.creatorde Albuquerque Pedrosa Fernandes, Taciana-
Autor(es): dc.creatorSallum, Adriana Maluf Elias-
Autor(es): dc.creatorCampos, Lucia Maria Arruda-
Autor(es): dc.creatorSakamoto, Ana Paula-
Autor(es): dc.creatorTerreri, Maria Teresa-
Autor(es): dc.creatorSztajnbok, Flavio Roberto-
Autor(es): dc.creatorBica, Blanca Elena Rios Gomes-
Autor(es): dc.creatorFerriani, Virginia Paes Leme-
Autor(es): dc.creatorde Carvalho, Luciana Martins-
Autor(es): dc.creatorSilva, Clovis Artur Almeida-
Autor(es): dc.creatorSaad-Magalhaes, Claudia-
Data de aceite: dc.date.accessioned2025-08-21T20:52:40Z-
Data de disponibilização: dc.date.available2025-08-21T20:52:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s42358-024-00353-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300794-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300794-
Descrição: dc.descriptionBackground: Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis. Method: A retrospective case-notes review, in a nationwide cohort from 27 Pediatric Rheumatology centres, with descriptive biopsy-proven malignancy, disease activity/damage accrual, and immunosuppressive treatment were compiled in each participating centre, using a standard protocol. Results: Of the 1757 cSLE cases in the updated cohort, 12 (0.7%) developed malignancy with median time 10 years after cSLE diagnosis. There were 91% females, median age at cSLE diagnosis 12 years, median age at malignancy diagnosis 23 years. Of all diagnosed malignancies, 11 were single-site, and a single case with concomitant multiple sites; four had haematological (0.22%) and 8 solid malignancy (0.45%). Median (min–max) SLEDAI-2 K scores were 9 (0–38), median (min–max) SLICC/ACR-DI (SDI) score were 1 (1–5) Histopathology defined 1 Hodgkin's lymphoma, 2 non-Hodgkin's lymphoma, 1 acute lymphoblastic leukaemia; 4 gastrointestinal carcinoma, 1 squamous cell carcinoma of the tongue and 1 anal carcinoma; 1 had sigmoid adenocarcinoma and 1 stomach carcinoid; 3 had genital malignancy, being 1 vulvae, 1 cervix and 1 vulvae and cervix carcinomas; 1 had central nervous system oligodendroglioma; and 1 testicle germ cell teratoma. Conclusion: Estimated malignancy frequency of 0.7% was reported during cSLE follow up in a multicentric series. Median disease activity and cumulative damage scores, by the time of malignancy diagnoses, were high; considering that reported in adult series.-
Descrição: dc.descriptionDepartment of Internal Medicine Discipline of Rheumatology Botucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Pediatrics Botucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Child and Adolescent Institute Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Universidade Federal de São Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Universidade Federal do Rio de Janeiro-
Descrição: dc.descriptionPediatric Rheumatology Unit Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho-
Descrição: dc.descriptionDepartment of Pediatrics Ribeirão Preto Medical School University of São Paulo, São Paulo-
Descrição: dc.descriptionAdolescent and Pediatric Rheumatology Units Child and Adolescent Institute HC-FMUSP Faculdade de Medicina da Universidade de São Paulo (FMUSP)-
Descrição: dc.descriptionPediatric Rheumatology Unit Department of Pathology Botucatu Medical School Sao Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine Discipline of Rheumatology Botucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Pediatrics Botucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Department of Pathology Botucatu Medical School Sao Paulo State University (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationAdvances in Rheumatology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChildhood-onset systemic lupus erithematosus-
Palavras-chave: dc.subjectLeukaemia-
Palavras-chave: dc.subjectLymphoma-
Palavras-chave: dc.subjectMalignancy-
Palavras-chave: dc.subjectRegistry-
Palavras-chave: dc.subjectSolid malignancy-
Título: dc.titleChildhood-onset systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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