Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNicoletti, Rafael Antunes-
Autor(es): dc.creatorde Souza, Thiago Pereira-
Autor(es): dc.creatorMiotto, Danyelle S.-
Autor(es): dc.creatorDuchatsch, Francine-
Autor(es): dc.creatorTardelli, Lidieli Pazin-
Autor(es): dc.creatorde Paula, Vinicius Ferreira-
Autor(es): dc.creatorAmaral, Sandra Lia-
Autor(es): dc.creatorZago, Anderson Saranz-
Data de aceite: dc.date.accessioned2025-08-21T23:42:00Z-
Data de disponibilização: dc.date.available2025-08-21T23:42:00Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2147/VHRM.S478482-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300790-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300790-
Descrição: dc.descriptionBackground: Aerobic training has been considered beneficial for determining the detrimental alterations in blood vessels caused by aging. Objective: Evaluate the relationship between the preventive effects of aerobic exercise and time of practice on cardiovascular health, in aged Wistar rats. Methods: Wistar rats (16 months) were divided into 3 groups: (1) sedentary (AGED); (2) long-term trained\61 weeks (LTT); and (3) short-term trained\final 8 weeks of life (STT). Body weight, maximum physical capacity, systolic blood pressure (SBP), pulse wave velocity (PWV), plasma nitrite (NO), oxidative stress (TBARS), wall thickness, the wall-to-lumen ratio, and collagen of the thoracic aorta, carotid, and femoral arteries were measured. Results: Both trained groups showed an increase in physical capacity when compared to the AGED group (p=<0.001 for LTT and p=0.011 for STT), and the LTT group demonstrated higher values when compared to the STT group (p= 0.004). The LTT group presented attenuation of PWV (p= 0.002) and a reduction in the wall thickness and wall-to-lumen ratio of the thoracic aorta (p=0.032 and 0.008, respectively) and carotid arteries (p=0.019 and 0.012, respectively) when compared to the AGED group. The STT group presented a reduction in TBARS compared to the AGED group (p=0.046). Additionally, both trained groups (LTT and STT) presented a reduction in the percentage of arterial collagen compared to the AGED group in the thoracic aorta (p=<0.001 and p=0.001 respectively) and carotid arteries (p= <0.008 and p= 0.041 respectively). Conclusion: This study demonstrated that long-term training decreased the level of collagen, PWV values, wall thickness, and the wall-to-lumen ratio of the aorta and carotid arteries compared to the AGED group. Moreover, short-term training reduced TBARS and collagen percentage in the aorta and carotid arteries compared to the AGED group.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionSao Paulo State University UNESP, SP-
Descrição: dc.descriptionPIPGCF Ufscar/UNESP-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionSao Paulo State University UNESP, SP-
Descrição: dc.descriptionPIPGCF Ufscar/UNESP-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format125-138-
Idioma: dc.languageen-
Relação: dc.relationVascular Health and Risk Management-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaerobic training-
Palavras-chave: dc.subjectaging-
Palavras-chave: dc.subjectarteries-
Palavras-chave: dc.subjectcollagen deposition-
Palavras-chave: dc.subjectpulse wave velocity-
Título: dc.titleAerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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