Objective assessment of tear film in blepharospasm, facial hemispam and aberrant regeneration with periocular botulinum toxin-A

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorHospital Universitario Rio Hortega-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGalindo-Ferreiro, Alicia-
Autor(es): dc.creatorFraile García, Marta-
Autor(es): dc.creatorSchellini, Silvana-
Autor(es): dc.creatorSanchez-Tocino, Hortensia-
Data de aceite: dc.date.accessioned2025-08-21T23:41:23Z-
Data de disponibilização: dc.date.available2025-08-21T23:41:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/11206721241266008-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300770-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300770-
Descrição: dc.descriptionPurpose: Study the effect on the tear film in blepharospasm (BEB), facial hemispasm (FH), or aberrant regeneration (AR) treated with Botulinum Toxin (BTX-A). Methods: A prospective study was used to evaluate the tear film in patients with BEB, FH, or AR treated with BTX-A. Schirmer tests, break-up time (BUT), optical coherence tomography (OCT) meniscus measurement, the Ocular Surface Disease Index (OSDI) questionnaire, and Oxford scale were documented before; 1 month after; and 3 months after BTX-A treatment. Comparisons were made with the Friedman test and Wilcoxon matched-pairs signed rank test was used. A p-value <0.05 was considered statistically significant. Results: A total of 35 eyes from 27 patients were included. The mean patient age was 66.81 ± 12.94 years and 18 (66.7%) were female. Ten (37%) patients had BEB, six (22.2%) had FH, and 11 (40.74%) had AR. BTX-A improved the lid spasms. One month after BTX-A, Schirmer tests showed slight increments (Schirmer 1 p = 0.009; Schirmer 2 p = 0.05) and at 3 months they became similar to pre-treatment (p = 0.5). The BUT test was not significantly different at 1 month (p = 0.450) or at 3 months. On OCT 1 month after BTX-A, there was an increase in tear meniscus area (p = 0.004), height (p = 0.007), and depth (p = 0.004), and at 3 months the measurements also became similar to the pre-BTX-A values. No significant changes in the OSDI (p = 0.717) and Oxford scale (p = 0.255). Conclusion: OCT is a good tool to detect the increase in tear meniscus after periocular BTX-A in BEB, FH, and AR.-
Descrição: dc.descriptionDepartment of Ophthalmology Hospital Universitario Rio Hortega-
Descrição: dc.descriptionDepartment of Ophthalmology Medical School State University of Sao Paulo (UNESP)-
Descrição: dc.descriptionDepartment of Ophthalmology Medical School State University of Sao Paulo (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Ophthalmology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectblepharospasm-
Palavras-chave: dc.subjectfacial hemispasm-
Palavras-chave: dc.subjectOCT-
Palavras-chave: dc.subjector aberrant regeneration-
Palavras-chave: dc.subjectperiocular botulinum toxin-
Palavras-chave: dc.subjecttear meniscus-
Título: dc.titleObjective assessment of tear film in blepharospasm, facial hemispam and aberrant regeneration with periocular botulinum toxin-A-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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