Evaluation of the Effects of Radiation Therapy on Muscle Contractibility and Skin Healing: An Experimental Study of the Cancer Treatment Implications

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTechnological Institute of Aeronautics (ITA)-
Autor(es): dc.creatorAvelino, Sarah O. M.-
Autor(es): dc.creatorNeves, Rafael M.-
Autor(es): dc.creatorSobral-Silva, Leonardo A.-
Autor(es): dc.creatorTango, Rubens N.-
Autor(es): dc.creatorFederico, Claudio A.-
Autor(es): dc.creatorVegian, Mariana R. C.-
Autor(es): dc.creatorde Almeida-Silva, Luis Augusto-
Autor(es): dc.creatorKaminagakura, Estela-
Autor(es): dc.creatorAmorim, José Benedito O.-
Autor(es): dc.creatorVasconcellos, Luana M. R.-
Data de aceite: dc.date.accessioned2025-08-21T17:05:36Z-
Data de disponibilização: dc.date.available2025-08-21T17:05:36Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/life13091838-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300767-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300767-
Descrição: dc.descriptionBackground: Radiotherapy can affect healthy cells, resulting in side effects. This study aimed to assess the impact of radiotherapy on soft tissue in surgical wounds in rats. Methods: The animals were divided into four groups: control (S) group without irradiation, immediate irradiation (S-IIr) group receiving irradiation right after surgery, late irradiation (S-LIr) group receiving irradiation four weeks after surgery, and early irradiation (Ir-S) group receiving irradiation before surgery. The irradiated groups underwent two fractional stages of 15 Gy. Muscle contractibility (EMG) was evaluated at two different time points, and after 2 and 7 weeks, the animals were euthanized for histological analysis of the muscles and skin. Results: There was no significant difference between the EMG1 and EMG2 values of the S and S-LIr groups, but both S-IIr and Ir-S groups exhibited a statistically significant difference. The S group demonstrated a larger diameter of muscle fiber compared to other groups, showing a significant difference. In terms of skin analysis, the S-IIr group had the least inflammatory infiltrate and the highest amount of red fibers, differing significantly from the other groups. Conclusions: Regardless of the duration, radiotherapy was found to have effects on the surrounding soft tissues, as concluded by this study.-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), Avenida Engenheiro Francisco José Longo, 777, Jardim São Dimas, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology São Paulo State University (UNESP), Avenida Engenheiro Francisco José Longo, 777, Jardim São Dimas, SP-
Descrição: dc.descriptionDepartment of Aerospace Science and Technology Institute of Advanced Studies Technological Institute of Aeronautics (ITA), Praça Marechal Eduardo Gomes, 50, Vila das Acacias, SP-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), Avenida Engenheiro Francisco José Longo, 777, Jardim São Dimas, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology São Paulo State University (UNESP), Avenida Engenheiro Francisco José Longo, 777, Jardim São Dimas, SP-
Idioma: dc.languageen-
Relação: dc.relationLife-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectelectromyography-
Palavras-chave: dc.subjectin vivo-
Palavras-chave: dc.subjectmuscle-
Palavras-chave: dc.subjectradiotherapy-
Palavras-chave: dc.subjectskin-
Título: dc.titleEvaluation of the Effects of Radiation Therapy on Muscle Contractibility and Skin Healing: An Experimental Study of the Cancer Treatment Implications-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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