Advancing Nanotechnology: Targeting Biofilm-Forming Bacteria with Antimicrobial Peptides

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLa Universidad Nacional de Ingeniería-
Autor(es): dc.contributorUniversidad Católica de Santa María de Arequipa-
Autor(es): dc.creatorCampos, Julia Valladares-
Autor(es): dc.creatorde Pontes, Janaína Teixeira Costa-
Autor(es): dc.creatorCanales, Christian Shleider Carnero-
Autor(es): dc.creatorRoque-Borda, Cesar Augusto-
Autor(es): dc.creatorPavan, Fernando Rogério-
Data de aceite: dc.date.accessioned2025-08-21T23:00:03Z-
Data de disponibilização: dc.date.available2025-08-21T23:00:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.34133/bmef.0104-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300747-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300747-
Descrição: dc.descriptionNanotechnology offers innovative solutions for addressing the challenges posed by biofilm-forming bacteria, which are highly resistant to conventional antimicrobial therapies. This review explores the integration of pharmaceutical nanotechnology with antimicrobial peptides (AMPs) to enhance the treatment of biofilm-related infections. The use of various nanoparticle systems—including inorganic/metallic, polymeric, lipid-based, and dendrimer nanostructures—provides promising avenues for improving drug delivery, targeting, and biofilm disruption. These nanocarriers facilitate the penetration of biofilms, down-regulate biofilm-associated genes, such as ALS1, ALS3, EFG1, and HWP1, and inhibit bacterial defense mechanisms through membrane disruption, reactive oxygen species generation, and intracellular targeting. Furthermore, nanoparticle formulations such as NZ2114-NPs demonstrate enhanced efficacy by reducing biofilm bacterial counts by several orders of magnitude. This review highlights the potential of combining nanotechnology with AMPs to create novel, targeted therapeutic approaches for combatting biofilm-related infections and overcoming the limitations of traditional antimicrobial treatments.-
Descrição: dc.descriptionSão Paulo State University (UNESP) Tuberculosis Research Laboratory School of Pharmaceutical Sciences-
Descrição: dc.descriptionFacultad de Ciencias La Universidad Nacional de Ingeniería-
Descrição: dc.descriptionVicerrectorado de Investigación Universidad Católica de Santa María de Arequipa-
Descrição: dc.descriptionSão Paulo State University (UNESP) Tuberculosis Research Laboratory School of Pharmaceutical Sciences-
Idioma: dc.languageen-
Relação: dc.relationBME Frontiers-
???dc.source???: dc.sourceScopus-
Título: dc.titleAdvancing Nanotechnology: Targeting Biofilm-Forming Bacteria with Antimicrobial Peptides-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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