Impact of ZrO2 Content on the Formation of Sr-Enriched Phosphates in Al2O3/ZrO2 Nanocomposites for Bone Tissue Engineering

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFundação Hermínio Ometto (FHO)-
Autor(es): dc.creatorNunes, Fabio Caixeta-
Autor(es): dc.creatorSantos, Sarah Ingrid Pinto-
Autor(es): dc.creatorColnago, Luiz Alberto-
Autor(es): dc.creatorHammer, Peter-
Autor(es): dc.creatorFerreira, Julieta Adriana-
Autor(es): dc.creatorAmbrósio, Carlos Eduardo-
Autor(es): dc.creatorPallone, Eliria Maria Jesus Agnolon-
Data de aceite: dc.date.accessioned2025-08-21T18:00:16Z-
Data de disponibilização: dc.date.available2025-08-21T18:00:16Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ma17081893-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300736-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300736-
Descrição: dc.descriptionThis study investigates the profound impact of the ZrO2 inclusion volume on the characteristics of Al2O3/ZrO2 nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15 vol% ZrO2, subjecting them to chemical surface treatment for enhanced calcium phosphate deposition sites. Biomimetic coating with Sr-enriched simulated body fluid (SBF) further enhanced the bioactivity of nanocomposites. While the ZrO2 concentration heightened the oxygen availability on nanocomposite surfaces, the quantity of Sr-containing phosphate was comparatively less influenced than the formation of calcium phosphate phases. Notably, the coated nanocomposites exhibited a high cell viability and no toxicity, signifying their potential in bone tissue engineering. Overall, these findings contribute to the development of regenerative biomaterials, holding promise for enhancing bone regeneration therapies.-
Descrição: dc.descriptionPostgraduate Programme in Materials Science and Engineering Faculty of Animal Science and Food Engineering (FZEA) University of São Paulo (USP), Av. Duque de Caxias Norte, 225, SP-
Descrição: dc.descriptionDepartment of Veterinary Medicine Faculty of Animal Science and Food Engineering (FZEA) University of São Paulo (USP), SP-
Descrição: dc.descriptionBrazilian Agricultural Research Corporation EMBRAPA Instrumentation, Rua Quinze de Novembro, 1500/1501, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFundação Hermínio Ometto Fundação Hermínio Ometto (FHO), Av. Dr. Maximiliano Baruto, 500, SP-
Descrição: dc.descriptionDepartment of Biosystem Engineering Faculty of Animal Science and Food Engineering (FZEA) University of São Paulo (USP), SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationMaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalumina-zirconia-
Palavras-chave: dc.subjectbiomaterial-
Palavras-chave: dc.subjectcalcium phosphates-
Palavras-chave: dc.subjectsurface treatment-
Título: dc.titleImpact of ZrO2 Content on the Formation of Sr-Enriched Phosphates in Al2O3/ZrO2 Nanocomposites for Bone Tissue Engineering-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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