Determination of the minimum alveolar concentration of sevoflurane in Holstein steers

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPrivate practitioner-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorFederal University of Juiz de Fora-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.creatorSantos, Paulo SP.-
Autor(es): dc.creatorGonzaga, Max S.-
Autor(es): dc.creatorAraújo, Marcelo A.-
Autor(es): dc.creatorDeschk, Mauricio-
Autor(es): dc.creatorde Siqueira, Carlos E.-
Autor(es): dc.creatorFloriano, Beatriz P.-
Autor(es): dc.creatorCancelli, Carlos HB.-
Data de aceite: dc.date.accessioned2025-08-21T21:10:01Z-
Data de disponibilização: dc.date.available2025-08-21T21:10:01Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.vaa.2023.06.001-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300731-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300731-
Descrição: dc.descriptionObjective: To determine the minimum alveolar concentration (MAC) of sevoflurane in Holstein steers using electric stimulation. Study design: Prospective experimental study. Animals: A total of 15 Holstein steers aged 7.3 ± 1.2 months and weighing 121 ± 25 kg. Methods: Animals were anesthetized with sevoflurane at 8% in oxygen at 5 L minute–1 via facemask and were intubated with an orotracheal tube of a compatible size. After 15 minutes of stabilization of the initial expired concentration of sevoflurane (FE′Sevo) at 2.6%, electrical stimulation on the thoracic limb was initiated with a sequence of 2 × 10 ms followed by 2 × 3 second electrical currents of 50 V and 50 Hz, 5 seconds apart. Following each stimulus with a negative response, the FE′Sevo was decreased by 0.2% and a 15 minute interval was awaited before the next stimulus. The procedure was repeated until the first FE′Sevo value with a positive motor response was obtained. The FE′Sevo was then increased by 0.1%, followed by a new stimulus, until a negative response was obtained. The value of MAC was calculated as the arithmetic mean between the lowest FE′Sevo associated with a negative motor response and the highest FE′Sevo associated with a positive response. Results: The mean MAC for the 15 steers was 2.0 ± 0.3%, which corresponds to 2.1 ± 0.3% at sea level. Conclusions: Based on the proposed methodology, the MAC of sevoflurane for healthy Holstein steers is 2.1 ± 0.3% at sea level. Clinical relevance: This FE′Sevo value can be used to guide depth of anesthesia in steers weighing approximately 120 kg in clinical practice.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Animal Clinic Surgery and Reproduction Faculty of Veterinary Medicine of Araçatuba São Paulo State University (UNESP), SP-
Descrição: dc.descriptionPrivate practitioner, SP-
Descrição: dc.descriptionVeterinary Teaching Hospital Federal University of Mato Grosso do Sul, MS-
Descrição: dc.descriptionVeterinary Teaching Hospital Federal University of Juiz de Fora, MG-
Descrição: dc.descriptionDepartment of Small Animal Clinic Centre of Rural Sciences Federal University of Santa Maria (UFSM), RS-
Descrição: dc.descriptionDepartment of Animal Clinic Surgery and Reproduction Faculty of Veterinary Medicine of Araçatuba São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2016/00405-9-
Formato: dc.format415-420-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Anaesthesia and Analgesia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbovine-
Palavras-chave: dc.subjectinhalation anesthesia-
Palavras-chave: dc.subjectruminants-
Palavras-chave: dc.subjectsteers-
Título: dc.titleDetermination of the minimum alveolar concentration of sevoflurane in Holstein steers-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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