A SIMPLE MATHEMATICAL MODEL OF NON-SMALL CELL LUNG CANCER INVOLVING MACROPHAGES AND CD8+ T CELLS

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorLourenço, Edgard-
Autor(es): dc.creatorRodrigues, Diego S.-
Autor(es): dc.creatorAntunes, Maria E.-
Autor(es): dc.creatorMancera, Paulo F.A.-
Autor(es): dc.creatorRodrigues, Guilherme-
Data de aceite: dc.date.accessioned2025-08-21T18:40:17Z-
Data de disponibilização: dc.date.available2025-08-21T18:40:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1142/S021833902350047X-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300716-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300716-
Descrição: dc.descriptionWe analyze biological processes interconnected to the tumor microenvironment development of non-small cell lung cancer (NSCLC), considering a proposed ordinary differential equation (ODE) model. The concepts of cancer as a disease, the cellular heterogeneity of the tumor microenvironment composition, and the macrophage cell epigenetic heterogeneity are presented, and the dynamics of the relations between them, the cytotoxic T cells and the neoplasm cells are explored. The apoptosis rate of the macrophage cells which present protumor characteristics is revealed as having a key role in the local stability of the ODE model. Furthermore, the hypothesis on the relevance of the CD8+ T cells in assisting the macrophage cells to control the tumor volume indicates a immunotherapeutic treatment possibility that considers both of these cells effectively.-
Descrição: dc.descriptionGraduate Program in Biometrics São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionSchool of Technology University of Campinas (UNICAMP), Limeira-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionGraduate Program in Biometrics São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), Botucatu-
Formato: dc.format1407-1431-
Idioma: dc.languageen-
Relação: dc.relationJournal of Biological Systems-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCancer Dynamics-
Palavras-chave: dc.subjectMacrophages-
Palavras-chave: dc.subjectSensitivity Analysis-
Palavras-chave: dc.subjectTIL Therapy-
Título: dc.titleA SIMPLE MATHEMATICAL MODEL OF NON-SMALL CELL LUNG CANCER INVOLVING MACROPHAGES AND CD8+ T CELLS-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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