Trichophyton rubrum inhibits Candida albicans filamentation and its gene expression when grown in biofilms in vitro

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversity of Florida College of Dentistry-
Autor(es): dc.contributorUniversity of Florida-
Autor(es): dc.creatorBila, Níura Madalena-
Autor(es): dc.creatorVaso, Carolina Orlando-
Autor(es): dc.creatorBelizário, Jenyffie Araújo-
Autor(es): dc.creatorSantoni Biasioli, Mariana M.-
Autor(es): dc.creatorFusco-Almeida, Ana Marisa-
Autor(es): dc.creatorMartinez, Luis R.-
Autor(es): dc.creatorCosta-Orlandi, Caroline Barcelos-
Autor(es): dc.creatorMendes-Giannini, Maria José Soares-
Data de aceite: dc.date.accessioned2025-08-21T15:32:21Z-
Data de disponibilização: dc.date.available2025-08-21T15:32:21Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0074-02760240221-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300674-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300674-
Descrição: dc.descriptionDermatomycoses are caused by various fungi, including dermatophytes and Candida species, which are the most prevalent in isolated or associated forms. A great number of virulence factors expressed by these fungi are important for infection, and biofilm formation leads to the persistence of these infections. This work aimed to evaluate the dynamics of Candida albicans filamentation genes in biofilms formed by Candida albicans and Trichophyton rubrum. The effect of the supernatants on the biofilms was assessed by XTT reduction assay, confocal microscopy, and gene expression profile analysis by real time-PCR. The supernatants did not reduce the metabolic activities or damage the topography of the monospecies biofilms but caused a reduction in their thickness. The filamentation of C. albicans was inhibited when both fungi were cultivated directly. The filamentation genes studied (CPH1, HWP1, and EFG1) were negatively modulated in C. albicans. Our findings suggest that the antagonistic relationship shown by T. rubrum against C. albicans may be attributed to alterations of C. albicans filamentous genes.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNational Institute of Allergy and Infectious Diseases-
Descrição: dc.descriptionSchool of Pharmaceutical Science-São Paulo State University (UNESP) Department of Clinical Analysis-
Descrição: dc.descriptionSchool of Veterinary-Eduardo Mondlane University (UEM) Department of Public and Animal Health-
Descrição: dc.descriptionSchool of Pharmaceutical Science-São Paulo State University (UNESP) Department of Biological Sciences-
Descrição: dc.descriptionDepartment of Oral Biology University of Florida College of Dentistry-
Descrição: dc.descriptionCenter for Translational Research in Neurodegenerative Disease University of Florida-
Descrição: dc.descriptionMcKnight Brain Institute University of Florida-
Descrição: dc.descriptionCenter for Immunology and Transplantation University of Florida-
Descrição: dc.descriptionEmerging Pathogens Institute University of Florida-
Descrição: dc.descriptionSchool of Pharmaceutical Science-São Paulo State University (UNESP) Department of Clinical Analysis-
Descrição: dc.descriptionSchool of Pharmaceutical Science-São Paulo State University (UNESP) Department of Biological Sciences-
Descrição: dc.descriptionCNPq: 134559/2018-5-
Descrição: dc.descriptionCNPq: 142049/2019-0-
Descrição: dc.descriptionFAPESP: 20022/15456-9-
Descrição: dc.descriptionFAPESP: 2017/18388-6-
Descrição: dc.descriptionFAPESP: 2018/02785-9-
Descrição: dc.descriptionFAPESP: 2019/22188-8-
Descrição: dc.descriptionFAPESP: 2020/15586-4-
Descrição: dc.descriptionFAPESP: 2021/03805-6-
Descrição: dc.descriptionNational Institute of Allergy and Infectious Diseases: AI145559-
Descrição: dc.descriptionNational Institute of Allergy and Infectious Diseases: AI187391-
Idioma: dc.languageen-
Relação: dc.relationMemorias do Instituto Oswaldo Cruz-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntagonism-
Palavras-chave: dc.subjectdermatomycoses; gene expression; virulence factors-
Palavras-chave: dc.subjectfilamentation-
Palavras-chave: dc.subjectmixed biofilms-
Título: dc.titleTrichophyton rubrum inhibits Candida albicans filamentation and its gene expression when grown in biofilms in vitro-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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