Inflammatory Profile of Chronic Rhinosinusitis With Nasal Polyp Patients in Brazil: Multicenter Study

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorUniversity of Brasília-
Autor(es): dc.contributorMedical Sciences University of Brasilia-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorCatholic University of Parana-
Autor(es): dc.contributorCuritiba-
Autor(es): dc.contributorFamerp-
Autor(es): dc.contributorGoiás Federal University-
Autor(es): dc.contributorFederal University of Goias-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorUniversidade Luterana do Brasil-
Autor(es): dc.contributorUniversidade Luterana do Brazil-
Autor(es): dc.contributorUniversidade do Estado do Rio de Janeiro (UERJ)-
Autor(es): dc.contributorFederal University of Rio Grande do Sul-
Autor(es): dc.contributorRhinology at Hospital de Clínicas de Porto Alegre-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.creatorRomano, Fabrizio R.-
Autor(es): dc.creatorValera, Fabiana C. P.-
Autor(es): dc.creatorFornazieri, Marco A.-
Autor(es): dc.creatorLopes, Natália M. D.-
Autor(es): dc.creatorMiyake, Marcel M.-
Autor(es): dc.creatorDolci, Ricardo L. L.-
Autor(es): dc.creatorNakanishi, Marcio-
Autor(es): dc.creatorFreire, Gustavo S. M.-
Autor(es): dc.creatorSakano, Eulália-
Autor(es): dc.creatorToro, Mariana D. C.-
Autor(es): dc.creatorKosugi, Eduardo M.-
Autor(es): dc.creatorGregorio, Luciano L.-
Autor(es): dc.creatordos Santos, Marco C. J.-
Autor(es): dc.creatorMurata, Juliana-
Autor(es): dc.creatorFernandes, Atilio M.-
Autor(es): dc.creatorMoras, Luis L.-
Autor(es): dc.creatorAvelino, Melissa A. G.-
Autor(es): dc.creatorCamargo, Leandro A.-
Autor(es): dc.creatorLessa, Marcus M.-
Autor(es): dc.creatorAlmeida, Laiana do C.-
Autor(es): dc.creatorRoithmann, Renato-
Autor(es): dc.creatorRedeker, Nicole-
Autor(es): dc.creatorTepedino, Miguel S.-
Autor(es): dc.creatorVianna, Pedro M.-
Autor(es): dc.creatorPiltcher, Otávio B.-
Autor(es): dc.creatorMeotti, Camila D.-
Autor(es): dc.creatorBezerra, Thiago F. P.-
Autor(es): dc.creatorVoegels, Richard L.-
Autor(es): dc.creatorde Mendonça Pilan, Renata R.-
Autor(es): dc.creatorBatista Murashima, Adriana de A.-
Autor(es): dc.creatorda Silva, Lilian E. C. M.-
Autor(es): dc.creatorArruda, Eurico-
Autor(es): dc.creatorGarcia, Denny M.-
Autor(es): dc.creatorTamashiro, Edwin-
Autor(es): dc.creatorAnselmo-Lima, Wilma-
Data de aceite: dc.date.accessioned2025-08-21T15:22:46Z-
Data de disponibilização: dc.date.available2025-08-21T15:22:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/ohn.904-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300671-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300671-
Descrição: dc.descriptionObjectives: To determine the inflammatory profile of CRSwNP in Brazil and characterize the subgroups of CRSwNP patients in this population through cluster analysis. Study Design: Multicenter cross-sectional study involving 15 centers representing different regions of Brazil. Subjects and Methods: Clinical data of 166 patients and 80 controls, aged 18 to 70 years old, number of surgeries for CRS, history of asthma and aspirin sensitivity, and Lund-Mackay scores on CT scans. During nasal endoscopy, we obtained the Lund-Kennedy scores and collected 2 samples of nasal polyps: one for eosinophil and neutrophil tissue counts and one to quantify different cytokines. Results: 79.6% of our patients had 10 or more eosinophils/HPF. CRSwNP groups exhibited significantly lower concentrations of TNF-alpha and significantly higher concentrations of IFN-gamma, CCL11/Eotaxin, CCL24/Eotaxin-2/MPIF-2, and CCL26/Eotaxin-3 versus the control group (Kruskal-Wallis test). Comparison between CRSwNP groups (≥10 vs <10 eosinophils/HPF) showed no difference in cytokine concentration (Mann-Whitney test). Hierarchical clustering and PCA according to cytokine concentrations revealed 2 main Clusters, with a significantly higher concentration of all cytokines in Cluster 1 (n = 35) than in Cluster 2 (n = 121), except IL-6 and IL-33 (Mann-Whitney test). According to ROC curve analysis the best cut-off to differentiate the 2 clusters was 43 eosinophils/HPF. The group with ≥43 presented a higher prevalence of men and a higher Lund-Mackay score (Mann-Whitney test). Conclusions: CRSwNP patients in Brazil present mixed inflammation, with 2 distinct groups (high and low inflammatory pattern) that can be distinguished by tissue eosinophilia of ≥43 eosinophils/HPF cut-off in nasal polyps.-
Descrição: dc.descriptionDepartment of Ophtalmology Otorhinolaryngology and Head and Neck Surgery University of Sao Paulo FMRP-USP-
Descrição: dc.descriptionOphthalmology Otorhinolaryngology Head and Neck Surgery Ribeirão Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Otorhinolaryngology State University of Londrina and PUC-Paraná-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Grupo de Excelência Médica State University of Londrina and PUC-Paraná-
Descrição: dc.descriptionDepartment of Otorhinolaryngology at Santa Casa de Misericórdia Hospital of São Paulo FMRP-USP-
Descrição: dc.descriptionDepartment of Otorhinolaryngology at Santa Casa de Misericórdia Hospital of São Paulo-
Descrição: dc.descriptionMedical School Graduate Program University of Brasília-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Medical Sciences University of Brasilia-
Descrição: dc.descriptionDepartment of Ophthalmology/Otorhinolaryngology of the Science Medical School of Sao Paulo State University-
Descrição: dc.descriptionDepartment of Otolaryngology Faculty of Medical Sciences State University of Campinas, São Paulo-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Head and Neck Surgery at Paulista School of Medicine Federal University of Sao Paulo-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Universidade Federal de São Paulo-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Catholic University of Parana-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Eco Medical Center Curitiba-
Descrição: dc.descriptionDepartment of Otorhinolaryngology and Head and Neck Surgery Famerp, São Paulo-
Descrição: dc.descriptionDepartment at Goiás Federal University Goiás Federal University-
Descrição: dc.descriptionDepartment of Otolaryngology Federal University of Goias-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Otorhinolaryngology of the Federal University of Bahia Medical School, Bahia-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Medical Sciences Federal University of Bahia Medical School, Bahia-
Descrição: dc.descriptionOtolaryngology Department of Otolaryngology–Head and Neck Surgery Universidade Luterana do Brasil-
Descrição: dc.descriptionDepartment of Otolaryngology–Head and Neck Surgery Mount Sinai Hospital-
Descrição: dc.descriptionDepartment of Otolaryngology–Head and Neck Surgery Universidade Luterana do Brazil, Rio Grande do Sul-
Descrição: dc.descriptionDivision of Clinical Otorhinolaryngology Hospital Universitário Pedro Ernesto Universidade do Estado do Rio de Janeiro Policlínica de Botafogo-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Medical Residency Program of Otorhinolaryngology at Army Central Hospital–RJ Rhinology and Skull Base Endoscopic Surgery Team at HUPE-UERJ-
Descrição: dc.descriptionDepartment of Otorhinolaryngology School of Medicine Federal University of Rio Grande do Sul-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Hospital de Clinicas de Porto Alegre Surgical Sciences at Universidade Federal do Rio Grande do Sul Rhinology at Hospital de Clínicas de Porto Alegre-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Federal University of Pernambuco-
Descrição: dc.descriptionDepartment of Otorhinolaryngology University of São Paulo-
Descrição: dc.descriptionDepartment of Ophthalmology Otorhinolaryngology Head and Neck Surgery Ribeirão Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Cell and Molecular Biology Virology Research Center Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Ophthalmology/Otorhinolaryngology of the Science Medical School of Sao Paulo State University-
Formato: dc.format1552-1561-
Idioma: dc.languageen-
Relação: dc.relationOtolaryngology - Head and Neck Surgery (United States)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchronic rhinosinusitis-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectphenotype-
Título: dc.titleInflammatory Profile of Chronic Rhinosinusitis With Nasal Polyp Patients in Brazil: Multicenter Study-
Tipo de arquivo: dc.typelivro digital-
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